尼可霉素 Z 与二苯基二硒醚联合抗申克孢子丝菌的协同作用

Synergism of Nikkomycin Z in Combination with Diphenyl Diselenide Against Sporothrix spp.

机构信息

Programa de Pós Graduação Em Ciências da Saúde, Faculdade de Medicina (FAMED), Universidade Federal Do Rio Grande (FURG), Rio Grande, RS, Brazil.

Laboratório de Micologia, FAMED, FURG, Campus Saúde. Visconde de Paranaguá 102, Centro, Rio Grande, RS, 96201-900, Brazil.

出版信息

Curr Microbiol. 2021 Aug;78(8):2905-2909. doi: 10.1007/s00284-021-02581-y. Epub 2021 Jun 28.

DOI:10.1007/s00284-021-02581-y

PMID:34181049

Abstract

We evaluated the in vitro activity of nikkomycin Z (NikZ) in combination with diphenyl diselenide (PhSe), two compounds previously shown to have anti-Sporothrix spp. activity. Eighteen isolates of Sporothrix spp. were tested in checkerboard assays. Synergism for inhibition and killing Sporothrix spp. occurred in 100% and 89% of the isolates, respectively. The anti-Sporothrix spp. activity of this combination provides a rationale for in vivo studies to evaluate the application of both compounds in sporotrichosis treatment.

摘要

我们评估了 nikkomycin Z（NikZ）与二苯基二硒（PhSe）联合使用的体外活性，这两种化合物先前已被证明具有抗申克孢子丝菌活性。检测了 18 株申克孢子丝菌分离株的棋盘微量稀释法实验。NikZ 和 PhSe 对申克孢子丝菌的抑制和杀伤协同作用分别达到 100%和 89%。该联合用药对申克孢子丝菌的活性为体内研究评估这两种化合物在孢子丝菌病治疗中的应用提供了依据。