评估与结缔组织病相关的间质性肺疾病患者的血清白细胞介素-6（IL-6）、IL-13 和 IL-17 水平及计算机断层扫描表现。
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients.
机构信息
Division of Rheumatology, Selcuk University Faculty of Medicine, 42130, Selcuklu, Konya, Turkey.
Division of Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey.
出版信息
Clin Rheumatol. 2021 Nov;40(11):4713-4724. doi: 10.1007/s10067-021-05773-w. Epub 2021 Jun 14.
OBJECTIVE
Interstitial lung disease (ILD) is one of the most severe complications which is associated with connective tissue disease (CTD) and causes to morbidity and mortality. So, we aimed to determine serum levels of interleukin-6 (IL-6), IL-13, and IL-17, to investigate whether these cytokines are related to CTD-ILD, and to find their possible contribution to determining the prognosis of the disease.
METHODS
A total of 150 participants, 80 patients diagnosed with CTD-ILD (mean age, 58.21 ± 12.36) and 70 healthy controls (mean age, 57.07 ± 9.60) were recruited from the rheumatology department between January 2016 and June 2019 in the study. High-resolution computed tomography (HRCT) findings were scored as similarly to previous studies. Serum IL-6, IL 13, and IL-17 levels were measured by ELISA test kits.
RESULTS
The levels of IL-6, IL-13, and IL-17 in CTD patients were significantly higher than the healthy individuals (p < 001), but the HRCT score's relation were not determined. IL-6 was associated with disease duration and disease activity scores of DAS28, ESDAII, and dSSc. There was a significant relation between dSSc, HCRT fibrosis, and total score.CRP, hemoglobin, and platelets were associated with the HRCT inflammation pattern.
CONCLUSION
At the study, it has been observed that serum IL-13, IL-6 and IL-17 levels are increased in patients with CTD-ILD. Besides, IL-6 was associated with disease activity scores of DAS28, ESDAII, and dSSc. Also, HRCT fibrosis score is associated with dSSc. Further and comprehensive studies are needed to understand better the complex intersection of lung disease with systemic autoimmunity. Key Points • Serum IL-13, IL-6, and IL-17 levels are increased in patients with CTD-ILD. • IL-6 was associated with disease activity scores of DAS28, ESDAII, and diffuse skin involvement. • HRCT fibrosis score is associated with diffuse skin involvement in patients with SSc-ILD. • HRCT inflammation score is associated with PAH.
目的
间质性肺病（ILD）是与结缔组织病（CTD）相关的最严重并发症之一，可导致发病率和死亡率。因此，我们旨在确定白细胞介素 6（IL-6）、IL-13 和 IL-17 的血清水平，研究这些细胞因子是否与 CTD-ILD 相关，并发现它们可能有助于确定疾病的预后。
方法
本研究共纳入 150 名参与者，其中 80 名 CTD-ILD 患者（平均年龄 58.21±12.36 岁）和 70 名健康对照者（平均年龄 57.07±9.60 岁）均于 2016 年 1 月至 2019 年 6 月期间在风湿科就诊。高分辨率计算机断层扫描（HRCT）评分与既往研究相似。采用 ELISA 试剂盒检测血清 IL-6、IL-13 和 IL-17 水平。
结果
CTD 患者的 IL-6、IL-13 和 IL-17 水平明显高于健康个体（p<0.001），但 HRCT 评分之间无相关性。IL-6 与疾病持续时间和 DAS28、ESDAII 和 dSSc 的疾病活动评分相关。dSSc、HRCT 纤维化和总分之间存在显著关系。CRP、血红蛋白和血小板与 HRCT 炎症模式相关。
结论
本研究观察到 CTD-ILD 患者血清 IL-13、IL-6 和 IL-17 水平升高。此外，IL-6 与 DAS28、ESDAII 和 dSSc 的疾病活动评分相关。而且，HRCT 纤维化评分与 dSSc 相关。需要进一步开展全面的研究，以更好地了解肺部疾病与系统性自身免疫之间的复杂交集。
关键点
CTD-ILD 患者的血清 IL-13、IL-6 和 IL-17 水平升高。
IL-6 与 DAS28、ESDAII 和弥漫性皮肤受累的疾病活动评分相关。
HRCT 纤维化评分与弥漫性皮肤受累的 SSc-ILD 患者相关。
HRCT 炎症评分与 PAH 相关。
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