• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of -Heteroaromatics and Cyclic Ethers.

作者信息

Qiu Zhong-Xuan, Dong Pei-Zhen, Zhao Huai-Li, Zhao Mei-Fa, Qiu Bin, Xiao Jian

机构信息

School of Biological and Chemical Engineering, Qingdao Technical College, Qingdao 266555, P.R. China.

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China.

出版信息

J Org Chem. 2021 Jul 16;86(14):9299-9305. doi: 10.1021/acs.joc.1c00337. Epub 2021 Jun 28.

DOI:10.1021/acs.joc.1c00337
PMID:34181422
Abstract

Brønsted acid-catalyzed direct C(sp)-H alkylation of -heteroaromatics with cyclic ethers via a cross-dehydrogenative coupling reaction in the presence of benzoyl peroxide was developed. This methodology successfully provided an easy access to a variety of alkyl-substituted quinoxaline, benzoimidazole, pyrazine, pyrimidine, quinoline, isoquinoline, and pyridine derivatives in up to 94% yield under metal-free conditions.

摘要

相似文献

1
Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of -Heteroaromatics and Cyclic Ethers.
J Org Chem. 2021 Jul 16;86(14):9299-9305. doi: 10.1021/acs.joc.1c00337. Epub 2021 Jun 28.
2
-Dehydrogenative Alkylation of Arenes with Ethers, Ketones, and Esters Catalyzed by Ruthenium.钌催化芳烃与醚、酮和酯的脱氢烷基化反应
Org Lett. 2020 Nov 20;22(22):8758-8763. doi: 10.1021/acs.orglett.0c02698. Epub 2020 Nov 5.
3
Iminoiodane- and Brønsted base-mediated cross dehydrogenative coupling of cyclic ethers with 1,3-dicarbonyl compounds.亚氨基碘烷和布朗斯特碱介导的环醚与1,3 - 二羰基化合物的交叉脱氢偶联反应
Molecules. 2015 Jul 22;20(7):13336-53. doi: 10.3390/molecules200713336.
4
Minisci-Type Dehydrogenative Coupling of C(sp)-H and N-Heteroaromatics Enabled by Photoelectrochemical Hydrogen Atom Transfer.光电化学氢原子转移实现的C(sp)-H与N-杂芳烃的Minisci型脱氢偶联反应
Org Lett. 2024 Jul 12;26(27):5805-5810. doi: 10.1021/acs.orglett.4c01998. Epub 2024 Jul 1.
5
Cross-dehydrogenative coupling of α-C(sp(3))-H of ethers/alkanes with C(sp(2))-H of heteroarenes under metal-free conditions.在无金属条件下醚/烷烃的α-C(sp(3))-H与杂芳烃的C(sp(2))-H的交叉脱氢偶联反应。
Org Biomol Chem. 2015 Dec 14;13(46):11341-50. doi: 10.1039/c5ob01268f. Epub 2015 Sep 30.
6
Iron-Catalyzed Regioselective α-C-H Alkylation of N-Methylanilines: Cross-Dehydrogenative Coupling between Unactivated C(sp)-H and C(sp)-H Bonds via a Radical Process.铁催化N-甲基苯胺的区域选择性α-C-H烷基化反应：通过自由基过程实现未活化C(sp³)-H与C(sp³)-H键之间的交叉脱氢偶联反应
J Org Chem. 2019 Jun 7;84(11):6830-6839. doi: 10.1021/acs.joc.9b00625. Epub 2019 May 29.
7
A transition metal-free Minisci reaction: acylation of isoquinolines, quinolines, and quinoxaline.无过渡金属的 Minisci 反应：异喹啉、喹啉和喹喔啉的酰化反应。
J Org Chem. 2014 May 2;79(9):3856-65. doi: 10.1021/jo500294z. Epub 2014 Apr 15.
8
Direct C2-alkylation of azoles with alcohols and ethers through dehydrogenative cross-coupling under metal-free conditions.在无金属条件下通过脱氢交叉偶联实现唑类与醇和醚的直接 C2-烷基化。
Org Lett. 2011 Oct 7;13(19):5016-9. doi: 10.1021/ol201779n. Epub 2011 Aug 29.
9
Cross-dehydrogenative coupling of azoles with α-C(sp3)-H of ethers and thioethers under metal-free conditions: functionalization of H-N azoles via C-H activation.无金属条件下唑类与醚和硫醚的α-C(sp3)-H的交叉脱氢偶联：通过C-H活化实现H-N唑类的官能化
J Org Chem. 2015 Feb 6;80(3):1929-36. doi: 10.1021/jo502477r. Epub 2015 Jan 28.
10
Acceptorless Dehydrogenative Coupling Using Ammonia: Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium.利用氨进行无受体脱氢偶联反应：钌催化二醇直接合成氮杂芳烃
J Am Chem Soc. 2018 Sep 26;140(38):11931-11934. doi: 10.1021/jacs.8b08385. Epub 2018 Sep 17.

引用本文的文献

1
Minisci Reaction by an MW-Boost: A Simple Protocol for Site-Selective Dehydrogenative Cross-Coupling Between Nitrogen-Aromatics and C(sp)─H Bonds.微波促进的Minisci反应：一种用于氮芳烃与C(sp)─H键之间位点选择性脱氢交叉偶联的简单方法。
Chemistry. 2025 Jun 6;31(32):e202501135. doi: 10.1002/chem.202501135. Epub 2025 May 6.
2
Synthesis of naphthalene derivatives via nitrogen-to-carbon transmutation of isoquinolines.通过异喹啉的氮到碳嬗变合成萘衍生物。
Sci Adv. 2025 Jan 31;11(5):eads5928. doi: 10.1126/sciadv.ads5928. Epub 2025 Jan 29.