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[减少全膝关节或髋关节置换患者输血的围手术期方案]

[Perioperative protocol to reduce blood transfusions in total knee o hip replacement patients].

作者信息

Godoy Alejandro, Gonzalez Jaqueline, Becerra Ana Florencia, Finola Mariano, Faule Facundo, Estrada Carlos, Neder Yamile, Albertini Ricardo

机构信息

Hospital Privado Universitario de Cordoba.

Hospital Privado Universitario de Córdoba .

出版信息

Rev Fac Cien Med Univ Nac Cordoba. 2021 Jun 28;78(2):110-117. doi: 10.31053/1853.0605.v78.n2.30134.

Abstract

INTRODUCTION

Patient Blood Management (PBM) programs improve patient care and reduce health costs. It includes detection of presurgical anemia, reduction of blood loss and improvement of patient-specific anemic reserve. The aim of this study is to assess the effect of a PBM program on transfusion rate, length of stay (LOS) and adverse events.

METHODS

We developed a retrospective observational study. We included patients who underwent total hip (THR) o knee replacement (TKR). Our PBM involved preoperative assessment, administration of 2 doses of tranexamic acid, application of restrictive transfusion criteria and use of IV iron. We compared results between the group of patients before and the one after the PBM implementation.

RESULTS

We included 179 patients (80 TKR and 99 THR) who underwent surgery before PBM implementation from January to December 2014 (Group A), and 187 patients (103 TKR and 84 THR) who underwent arthroplasty after PBM application from January to November 2016 (Group B). In Group A, hemoglobin drop was larger than in Group B, for TKR (5.1±1.2 vs. 4.2±1.2 g/dl; p<0,05) and for THR (4.7±1.3 vs. 3.8±1.3 g/dl; p<0,05). In group A, more patients were transfused (31.8% vs. 2.7%; p<0.001). LOS was longer for patients in group A, in both surgeries (for TKA, 3.98±1.4days vs. 2.99±0.95 days; p<0.0001; for THA 3.68±1.06days vs. 2.88±0.75days; p<0.0001). No significant differences were found regarding adverse events.

CONCLUSION

Our PBM program saved transfusions after primary TKR and THR and lowered LOS, without risking patients to higher number of complications or death.

摘要

引言

患者血液管理(PBM)项目可改善患者护理并降低医疗成本。它包括术前贫血的检测、失血的减少以及患者特异性贫血储备的改善。本研究的目的是评估PBM项目对输血率、住院时间(LOS)和不良事件的影响。

方法

我们开展了一项回顾性观察研究。纳入接受全髋关节置换术(THR)或膝关节置换术(TKR)的患者。我们的PBM包括术前评估、给予2剂氨甲环酸、应用限制性输血标准以及使用静脉铁剂。我们比较了PBM实施前和实施后两组患者的结果。

结果

我们纳入了2014年1月至12月在PBM实施前接受手术的179例患者(80例TKR和99例THR)(A组),以及2016年1月至11月在PBM应用后接受关节置换术的187例患者(103例TKR和84例THR)(B组)。在A组中,TKR患者(5.1±1.2 vs. 4.2±1.2 g/dl;p<0.05)和THR患者(4.7±1.3 vs. 3.8±1.3 g/dl;p<0.05)的血红蛋白下降幅度大于B组。在A组中,更多患者接受了输血(31.8% vs. 2.7%;p<0.001)。在这两种手术中,A组患者的住院时间更长(TKA:3.98±1.4天 vs. 2.99±0.95天;p<0.0001;THA:3.68±1.06天 vs. 2.88±0.75天;p<0.0001)。在不良事件方面未发现显著差异。

结论

我们的PBM项目在初次TKR和THR后节省了输血并缩短了住院时间,且未使患者面临更多并发症或死亡风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd6e/8741308/05ac2cd6f0d6/1853-0605-78-2-110-gf001.jpg

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