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[危重症成年患者有创机械通气相关的膈肌功能障碍]

[Diaphragmatic dysfunction associated with invasive mechanical ventilation in critically ill adult patients].

作者信息

Tocalini Pablo, Vicente Antonela, Carballo Juan Manuel, Garegnani Luis Ignacio

机构信息

Clínica Basilea, Solís 1025, C1078, CABA, Argentina..

Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, CP1406, CABA, Argentina..

出版信息

Rev Fac Cien Med Univ Nac Cordoba. 2021 Jun 28;78(2):197-206. doi: 10.31053/1853.0605.v78.n2.28458.

DOI:10.31053/1853.0605.v78.n2.28458
PMID:34181847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8741307/
Abstract

Invasive mechanical ventilation (VMI) is a life support therapy that is not free of complications, such as ventilator induced diaphragmatic dysfunction, which is characterized by atrophy and weakness of the muscle. Interest in this pathology seems to be based on the association found with negative clinical results. The prevalence ranges between 29 and 80%, probably due to the variability between the different diagnostic methods and the time of evaluation. The gold standard continues to be the transdiaphragmatic negative pressure generated by the bilateral stimulation of the phrenic nerves, although due to the lack of practicality, diaphragmatic ultrasound began to be used. Although it has several modalities, not all of them have correlation analysis with the gold standard. Another problem arises when analyzing the independent association between pathology and VMI, since confusing factors are not easy to isolate.

摘要

有创机械通气(VMI)是一种并非没有并发症的生命支持疗法,例如呼吸机诱发的膈肌功能障碍,其特征是肌肉萎缩和无力。对这种病理状况的关注似乎基于所发现的与负面临床结果的关联。患病率在29%至80%之间,这可能是由于不同诊断方法和评估时间的差异所致。尽管由于缺乏实用性,膈超声开始被使用,但金标准仍然是双侧刺激膈神经产生的跨膈负压。虽然它有多种方式,但并非所有方式都与金标准有相关性分析。在分析病理状况与VMI之间的独立关联时还会出现另一个问题,因为混杂因素不容易分离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/8741307/f9f96ff71bc7/1853-0605-78-2-197-gf001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/8741307/f9f96ff71bc7/1853-0605-78-2-197-gf001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/8741307/f9f96ff71bc7/1853-0605-78-2-197-gf001.jpg

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本文引用的文献

1
Diaphragm Weakness in the Critically Ill: Basic Mechanisms Reveal Therapeutic Opportunities.危重症患者膈肌无力:基础机制揭示治疗机会。
Chest. 2018 Dec;154(6):1395-1403. doi: 10.1016/j.chest.2018.08.1028. Epub 2018 Aug 23.
2
Diaphragm function and weaning from mechanical ventilation: an ultrasound and phrenic nerve stimulation clinical study.膈肌功能与机械通气撤机:一项超声与膈神经刺激的临床研究。
Ann Intensive Care. 2018 Apr 23;8(1):53. doi: 10.1186/s13613-018-0401-y.
3
Using M-mode ultrasonography to assess diaphragm dysfunction and predict the success of mechanical ventilation weaning in elderly patients.
使用M型超声心动图评估老年患者的膈肌功能障碍并预测机械通气撤机的成功率。
J Thorac Dis. 2017 Sep;9(9):3177-3186. doi: 10.21037/jtd.2017.08.16.
4
Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes.机械通气导致的膈肌萎缩严重影响临床结局。
Am J Respir Crit Care Med. 2018 Jan 15;197(2):204-213. doi: 10.1164/rccm.201703-0536OC.
5
Ventilator-Induced Diaphragmatic Dysfunction: Diagnosis and Role of Pharmacological Agents.呼吸机诱发的膈肌功能障碍:诊断及药物的作用
Respir Care. 2017 Nov;62(11):1485-1491. doi: 10.4187/respcare.05622. Epub 2017 Jul 11.
6
Ultrasound evaluation of diaphragm function in mechanically ventilated patients: comparison to phrenic stimulation and prognostic implications.机械通气患者膈肌功能的超声评估:与膈神经刺激的比较及预后意义。
Thorax. 2017 Sep;72(9):811-818. doi: 10.1136/thoraxjnl-2016-209459. Epub 2017 Mar 30.
7
Diaphragm Muscle Thinning in Subjects Receiving Mechanical Ventilation and Its Effect on Extubation.接受机械通气患者的膈肌变薄及其对拔管的影响。
Respir Care. 2017 Jul;62(7):904-911. doi: 10.4187/respcare.05370. Epub 2017 Mar 28.
8
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.术中半膈肌电刺激可降低接受机械通气的手术患者的氧化应激并上调自噬:探索性研究。
J Transl Med. 2016 Oct 26;14(1):305. doi: 10.1186/s12967-016-1060-0.
9
Diaphragmatic Dysfunction Is Characterized by Increased Duration of Mechanical Ventilation in Subjects With Prolonged Weaning.膈肌功能障碍的特征是脱机时间延长的患者机械通气时间增加。
Respir Care. 2016 Oct;61(10):1316-22. doi: 10.4187/respcare.04746.
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Assessment of diaphragmatic dysfunction in the critically ill patient with ultrasound: a systematic review.超声评估危重症患者膈肌功能障碍:系统评价。
Intensive Care Med. 2017 Jan;43(1):29-38. doi: 10.1007/s00134-016-4524-z. Epub 2016 Sep 12.