Laboratorio de Células Madre en Cáncer y Envejecimiento, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
Laboratorio de Células Madre en Cáncer y Envejecimiento, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.
Mech Ageing Dev. 2021 Sep;198:111528. doi: 10.1016/j.mad.2021.111528. Epub 2021 Jun 25.
The capacity to regenerate damaged or lost tissue varies widely along the animal kingdom and generally declines with aging of the organism. The gradual accumulation of senescent cells in tissues during aging has been causally involved in their reduced function at old age, and to be at the basis of age-related diseases. Recently, however, cellular senescence has been shown to play a positive role as a morphogenetic force modelling and promoting tissue development during embryogenesis, and to be responsible for tissue wound healing and repair. Work done on organismal models ranging from fish and amphibians, with extraordinary regenerative capacities, to mammals, with a more restricted regenerative potential, is shedding light on a novel and unexpected function of cellular senescence. In this review, we will analyze the senescence phenotype and how could it be contributing or restricting tissue regeneration.
再生受损或丢失组织的能力在动物王国中差异很大，并且通常随着生物体的衰老而下降。衰老过程中组织中衰老细胞的逐渐积累与它们在老年时功能下降有关，是导致与年龄相关疾病的基础。然而，最近的研究表明，细胞衰老作为一种形态发生力，在胚胎发生过程中对组织发育具有积极作用，并负责组织创伤愈合和修复。从具有非凡再生能力的鱼类和两栖类动物到具有更有限再生潜力的哺乳动物的生物体模型的研究工作揭示了细胞衰老的一种新的、意想不到的功能。在这篇综述中，我们将分析衰老表型，以及它如何促进或限制组织再生。
