Howard University College of Medicine, Washington, DC.
Division of Urology, Department of Surgery, Howard University Hospital, Washington, DC.
Urology. 2021 Oct;156:e40-e47. doi: 10.1016/j.urology.2021.06.010. Epub 2021 Jun 26.
Sickle cell disease (SCD) is an inherited medical condition where sickled red blood cells cause vaso-occlusive crisis. One major complication of SCD is priapism, defined as an erection of the penis lasting over four hours beyond sexual stimulation or orgasm. SCD priapism is caused by sickled erythrocytes obstructing venous outflow and can lead to permanent erectile dysfunction. This article reviews the pathology, physiology, and management of SCD priapism, including potential novel therapeutic agents.
镰状细胞病（SCD）是一种遗传性疾病，镰状红细胞导致血管阻塞性危象。SCD 的一个主要并发症是阴茎异常勃起，定义为在性刺激或性高潮后超过四小时的阴茎勃起。SCD 异常勃起是由镰状红细胞阻塞静脉流出引起的，并可导致永久性勃起功能障碍。本文综述了 SCD 异常勃起的病理学、生理学和治疗方法，包括潜在的新型治疗药物。
