Mateus Rita, Fuhrmann Jana F, Dye Natalie A
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany; Cluster of Excellence Physics of Life, Technische Universität Dresden, 01062 Dresden, Germany.
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Curr Opin Cell Biol. 2021 Dec;73:50-57. doi: 10.1016/j.ceb.2021.05.002. Epub 2021 Jun 26.
Organ and tissue growth result from an integration of biophysical communication across biological scales, both in time and space. In this review, we highlight new insight into the dynamic connections between control mechanisms operating at different length scales. First, we consider how the dynamics of chemical and electrical signaling in the shape of gradients or waves affect spatiotemporal signal interpretation. Then, we discuss the mechanics underlying dynamic cell behavior during oriented tissue growth, followed by the connections between signaling at the tissue and organismal levels.
器官和组织的生长源于生物尺度上生物物理通讯在时间和空间上的整合。在本综述中，我们着重介绍关于在不同长度尺度上运行的控制机制之间动态联系的新见解。首先，我们思考以梯度或波的形式存在的化学和电信号传导动力学如何影响时空信号解读。然后，我们讨论定向组织生长过程中动态细胞行为背后的力学原理，接着探讨组织和机体水平信号传导之间的联系。
