Hospital Moinhos de Vento, Porto Alegre, Brazil.
National Immunization Program, Ministry of Health, Brasília, Brazil.
Oral Oncol. 2021 Sep;120:105396. doi: 10.1016/j.oraloncology.2021.105396. Epub 2021 Jun 25.
This study aimed to report the national prevalence of oral HPV infection among unvaccinated women and men aged 16-25 years who utilized the public primary care services.
POP-Brazil is a cross-sectional, multicentric, nationwide survey conducted between September 2016 and November 2017. Recruitment was based in 119 public primary care practices in 26 state capitals and the Federal District of Brazil. Trained health professionals conducted face-to-face interviews. Oral samples were collected with mouthwash and gargle cycles. Genotyping was performed using the Roche PCR-based linear array genotyping test. Sampling weights by sex and age were applied.
Valid oral HPV samples were collected from 5071 (96.88%) participants; 4005 women and 1066 men. Mean participant age was 21.63 years. Overall HPV prevalence was 1.69% (n = 73, 95% CI 1.05-2.32). Thirty individuals presented at least one high-risk HPV type [0.57% (95% CI, 0.29-0.85)]. There were no associations between age, sex, sociodemographic characteristics, drug use or sexual behavior and oral HPV prevalence.
The prevalence of oral HPV infection in Brazilian teenagers and young adults is low, with no sociodemographic or behavioral correlates.
本研究旨在报告未接种疫苗的 16-25 岁女性和男性在利用公共初级保健服务时的口腔 HPV 感染全国流行率。
POP-Brazil 是一项于 2016 年 9 月至 2017 年 11 月间开展的横断面、多中心、全国性调查。招募工作基于巴西 26 个州首府和联邦区的 119 家公共初级保健机构进行。经过培训的卫生专业人员进行了面对面访谈。使用漱口水和含漱周期采集口腔样本。采用罗氏基于 PCR 的线性阵列基因分型检测进行基因分型。按性别和年龄应用采样权重。
从 5071 名（96.88%）参与者中采集了有效的口腔 HPV 样本；其中女性 4005 人，男性 1066 人。平均参与者年龄为 21.63 岁。总体 HPV 流行率为 1.69%（n=73，95%CI 1.05-2.32）。有 30 人至少存在一种高危 HPV 型别[0.57%（95%CI，0.29-0.85）]。年龄、性别、社会人口统计学特征、药物使用或性行为与口腔 HPV 流行率之间无关联。
巴西青少年和年轻成年人的口腔 HPV 感染流行率较低，与社会人口学或行为因素无关。
