Fondation FondaMental, Créteil, France; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, AP-HP, DMU IMPACT, FHU ADAPT, Fondation FondaMental, F-94010 Créteil, France.
APHP, Sorbonne Université, Département Medico-Universitaire Neurosciences, Unité de Psychiatrie, Psychotraumatologie et Addictions, Hôpital Tenon, Paris, France.
Psychoneuroendocrinology. 2021 Sep;131:105327. doi: 10.1016/j.psyneuen.2021.105327. Epub 2021 Jun 15.
As compared to the general population, adult individuals with bipolar disorders (BD) have higher mortality rates due to cardiovascular diseases and higher prevalence of Metabolic Syndrome (MetS). Recent evidence suggests that childhood maltreatment may contribute to the cardiovascular burden in individuals with BD. However, studies are scarce, with limited sample sizes and inconsistent results. We explored the associations between a self-reported history of childhood maltreatment and MetS (and its subcomponents) in a large sample of 2390 individuals with BD. Childhood maltreatment was assessed using the Childhood Trauma Questionnaire and MetS was defined according to the revised criteria of the ATEP III. We suggested associations between childhood maltreatment and the presence of MetS in men and in younger individuals. The association between childhood maltreatment and the presence of MetS in the early onset subgroup was not significant after adjustment for site of recruitment and level of education. Hence, some links between childhood maltreatment and MetS might exist only in specific subgroups of individuals with BD, but confirmation is required in independent and large samples, while taking into account potential confounders. This would help defining how psychosocial interventions that target childhood maltreatment and its consequences may be beneficial for physical health.
与一般人群相比，患有双相情感障碍（BD）的成年人由于心血管疾病导致的死亡率更高，且代谢综合征（MetS）的患病率更高。最近的证据表明，童年期虐待可能导致 BD 患者的心血管负担加重。然而，相关研究较少，样本量有限，结果不一致。我们在一个由 2390 名 BD 患者组成的大样本中，探索了自我报告的童年期虐待史与代谢综合征（及其亚组分）之间的关联。使用儿童期创伤问卷评估童年期虐待，根据 ATEP III 的修订标准定义代谢综合征。我们提出了在男性和年轻个体中，童年期虐待与代谢综合征存在的相关性。经过调整招募地点和教育水平后，童年期虐待与早发性亚组中代谢综合征存在的相关性不再显著。因此，童年期虐待与代谢综合征之间的一些联系可能仅存在于 BD 患者的特定亚组中，但需要在独立的大样本中进行证实，并考虑到潜在的混杂因素。这将有助于确定针对童年期虐待及其后果的心理社会干预措施如何有益于身体健康。
