基于四维 CT 图像和呼吸门控放疗中屏气的替代引导注册的残余设定误差：肝癌的研究。
Residual Set Up Errors of the Surrogate-guided Registration Using Four-dimensional CT Images and Breath Holding Ones in Respiratory Gated Radiotherapy for Liver Cancer.
机构信息
Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan;
Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
出版信息
In Vivo. 2021 Jul-Aug;35(4):2089-2098. doi: 10.21873/invivo.12478.
BACKGROUND/AIM: To evaluate the surrogate-guided registration accuracy of two computed tomography (CT) image sets, expiratory phase four-dimensional (Ex4D) CT and breath-holding CT (BHCT), in respiratory-gated radiotherapy for liver cancer.
MATERIALS AND METHODS
The surrogate-guided registration errors were defined as the differences between the diaphragm- and fiducial-guided registrations or the differences between upper and lower fiducial registrations in three directions: left-right (LR), anterior-posterior (AP), and cranio-caudal (CC).
RESULTS
The mean±SDs of the absolute errors for diaphragm-guided registration were 1.9±1.3, 2.7±1.8, and 2.6±1.7 mm with Ex4D and 1.8±1.8, 2.6±1.9, and 1.8±1.7 mm with BHCT in the LR, AP and CC directions, respectively (CC direction, p<0.01). In the fiducial-guided registration, there were no significant differences in any direction. In registration with Ex4D, there were positive correlations between registration errors and the respiratory irregularity during 4D scanning (correlation coefficient; diaphragm: 0.65, fiducial: 0.54).
CONCLUSION
BHCT has the advantage of accurate surrogate-guided registration compared with Ex4D.
背景/目的：评估两种 CT 图像（呼气末 4DCT 和屏气 CT）在肝癌呼吸门控放疗中，基于替代物引导的配准精度。
材料和方法
替代物引导的配准误差定义为膈肌和基准引导配准之间的差异，或在三个方向（左右、前后和头脚）的上下基准配准之间的差异。
结果
Ex4D 和 BHCT 在左右、前后和头脚方向的膈肌引导配准的绝对误差均值±标准差分别为 1.9±1.3mm、2.7±1.8mm 和 2.6±1.7mm（头脚方向，p<0.01）。在基准引导配准中，在任何方向上均无显著差异。在 Ex4D 配准中，注册误差与 4D 扫描期间的呼吸不规则性之间存在正相关（相关系数；膈肌：0.65，基准：0.54）。
结论
与 Ex4D 相比，BHCT 在基于替代物引导的配准方面具有优势。
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