Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;
Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
In Vivo. 2021 Jul-Aug;35(4):2305-2312. doi: 10.21873/invivo.12504.
To evaluate the efficacy of chemoembolization versus radioembolization in reducing lung shunt fraction (LSF) in patients with hepatocellular carcinoma (HCC).
In this retrospective study, from March 2012 to January 2021, 457 patients with HCC underwent planning angiography and Tc-macroaggregated albumin imaging for possible yttrium-90 radioembolization. Ten patients underwent radioembolization, and seven patients underwent conventional chemoembolization for LSF reduction, and a second Tc-macroaggregated albumin imaging was obtained approximately 1 month later. LSF under both procedures was compared with the Mann-Whitney U-test and the Wilcoxon signed-rank test.
In the radioembolization group, the mean first and second LSF were 13.0±6.9% and 20.9±9.6%, respectively (p=0.059); after radioembolization, LSF was lower in three patients but higher in seven patients. In the chemoembolization group, the mean first and second LSF were 26.1±17.3% and 8.7±5.5%, respectively (p=0.018); after chemoembolization, LSF was reduced in all seven patients.
Chemoembolization appears to be more effective in reducing LSF within 1 month compared with radioembolization.
评估化疗栓塞与放射性栓塞在降低肝细胞癌（HCC）患者肺分流分数（LSF）方面的疗效。
本回顾性研究纳入了 2012 年 3 月至 2021 年 1 月期间，457 例拟行钇-90 放射性栓塞的 HCC 患者。10 例患者接受了放射性栓塞治疗，7 例患者接受了常规化疗栓塞以降低 LSF，并在大约 1 个月后再次进行 Tc-巨聚合白蛋白成像。采用 Mann-Whitney U 检验和 Wilcoxon 符号秩检验比较两种方法下的 LSF。
在放射性栓塞组中，首次和第二次 LSF 的均值分别为 13.0±6.9%和 20.9±9.6%（p=0.059）；放射性栓塞后，3 例患者的 LSF 降低，7 例患者的 LSF 升高。在化疗栓塞组中，首次和第二次 LSF 的均值分别为 26.1±17.3%和 8.7±5.5%（p=0.018）；化疗栓塞后，7 例患者的 LSF 均降低。
与放射性栓塞相比，化疗栓塞在 1 个月内降低 LSF 的效果似乎更显著。
