Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
In Vivo. 2021 Jul-Aug;35(4):2349-2355. doi: 10.21873/invivo.12511.
This study aimed to determine whether the prognostic nutritional index (PNI) can predict the prognosis in patients with soft-tissue sarcoma (STS) before treatment and to examine whether there is an association between PNI values and clinical characteristics.
The data on 100 patients with primary STS were retrospectively reviewed. The cohort included 55 men and 45 women, with a mean age of 64 years. The mean follow-up duration was 41.7 months.
The median PNI was 51.35. The PNI was significantly inversely associated with tumor size, tumor grade, and age. We found that the PNI was a significant prognostic marker for disease-specific and event-free survival using univariate and multivariate analyses. Patients with a low PNI had poorer disease-specific and event-free survival than those with a high PNI.
These results suggest that the PNI can be used as a prognostic marker in patients with STS.
本研究旨在确定预后营养指数（PNI）是否可以预测治疗前软组织肉瘤（STS）患者的预后，并探讨 PNI 值与临床特征之间是否存在关联。
回顾性分析了 100 例原发性 STS 患者的数据。该队列包括 55 名男性和 45 名女性，平均年龄为 64 岁。平均随访时间为 41.7 个月。
PNI 的中位数为 51.35。PNI 与肿瘤大小、肿瘤分级和年龄呈显著负相关。我们发现，使用单变量和多变量分析，PNI 是疾病特异性和无事件生存的显著预后标志物。PNI 低的患者疾病特异性和无事件生存率低于 PNI 高的患者。
这些结果表明，PNI 可作为 STS 患者的预后标志物。
