Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Aging (Albany NY). 2021 Jun 28;13(12):16859-16872. doi: 10.18632/aging.203200.
The ADAMs (a disintegrin and metalloproteinase) are a family of cell surface proteins with crucial roles in the regulation of cell adhesion, cell proliferation to migration, proteolysis and cell signaling transduction pathways. Among these enzymes, the ADAM17 shows significant effects in the "ectodomain shedding" of its substrates such as cytokines (e.g., tumor necrosis factor α, TNFα), growth factors (e.g., epidermal growth factor, EGF), adhesion proteins (e.g., L-selectin), and their receptors (e.g., IL-6R and TNFα). Several studies focus on the underlying molecular mechanisms of ADAM17 in diseased conditions. Here, we took several different approaches to elucidate the function of ADAM17, the participation of ADAM17 in several human diseases, and the potential as targeted therapy reagents. As more and more studies verify the miRNA-mediated expression variation of ADAM17, the specific regulation network of miRNAs and ADAM17 was exploited in this review as well.
解整合素金属蛋白酶（ADAMs）是细胞表面蛋白家族，在细胞黏附、细胞增殖到迁移、蛋白水解和细胞信号转导途径的调控中起关键作用。在这些酶中，ADAM17 对其底物（如细胞因子（如肿瘤坏死因子 α，TNFα）、生长因子（如表皮生长因子，EGF）、黏附蛋白（如 L-选择素）及其受体（如 IL-6R 和 TNFα）的“外显肽脱落”有显著影响。一些研究集中在 ADAM17 在疾病状态下的潜在分子机制上。在这里，我们采用了几种不同的方法来阐明 ADAM17 的功能、ADAM17 在几种人类疾病中的参与以及作为靶向治疗试剂的潜力。随着越来越多的研究验证了 ADAM17 的 miRNA 介导的表达变化，本综述还探讨了 miRNA 和 ADAM17 的特定调节网络。
