Keys A
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.
J Epidemiol Community Health. 1988 Mar;42(1):60-5. doi: 10.1136/jech.42.1.60.
In the Twin Cities Prospective Study, executive men aged 45 to 55 and "healthy" at the entry examinations in 1948 were re-examined yearly to 1975. Follow-up through 1983 lost only one man. High density lipoprotein cholesterol (HDL) in the serum was measured in 1955 with a method checked with recent standard methods. Among 217 men, 130 were dead by 1983, 56 from coronary heart disease (CHD) and 27 from neoplasms. Survivors did not differ in mean HDL from the men who died but they had higher values than the men dead from CHD. Men dead from neoplasms had significantly higher HDL than men dead from CHD. Men dying early did not differ in HDL from those dying later but they had higher blood pressures. HDL was unrelated to age at death from all causes but was related to age at death from CHD. HDL was not related to age, total cholesterol, smoking, or respiratory function but was negatively correlated with measures of body fatness. Multiple regression and multiple logistic analyses showed no difference in HDL between survivors and men dead from all causes, but men dead from CHD tended to have lower HDL. The data indicate that longevity is not related to HDL in middle age.
在双城前瞻性研究中，1948年入组检查时年龄在45至55岁且“健康”的男性行政人员，每年接受复查直至1975年。随访至1983年时仅失访1人。1955年采用与近期标准方法校准过的方法测量血清中的高密度脂蛋白胆固醇（HDL）。在217名男性中，到1983年时有130人死亡，其中56人死于冠心病（CHD），27人死于肿瘤。幸存者的平均HDL水平与死亡者无差异，但高于死于冠心病的男性。死于肿瘤的男性HDL水平显著高于死于冠心病的男性。过早死亡者的HDL水平与较晚死亡者无差异，但前者血压更高。HDL与各种原因导致的死亡年龄无关，但与冠心病导致的死亡年龄有关。HDL与年龄、总胆固醇、吸烟或呼吸功能无关，但与身体肥胖指标呈负相关。多元回归和多元逻辑分析显示，幸存者与各种原因死亡者的HDL水平无差异，但死于冠心病的男性HDL水平往往较低。数据表明，中年人的长寿与HDL无关。
