Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North; Guangzhou 510515, PR China.
School of Chemical Engineering and Resource Recycling, Wuzhou University, 82 Fumin 3rd Road; Wuzhou, Guangxi 543002, P.R. China.
Curr Med Chem. 2021;28(42):8673-8691. doi: 10.2174/0929867328666210628144347.
Nonactic acid, which is a macrocyclic nonactin subunit, contains four asymmetric centers and has the molecular formula of C10H18O3. Due to their various biological activities and challenging structural characteristics, nonactic acid and its derivatives have attracted much attention from scientists since 1955. These compounds possess significant antibacterial, insecticidal and acaricidal activities, as well as a promoting effect on plant growth. However, the studies in the anticancer activities of these compounds are limited. It is noticed that some derivatives of nonactic acid show significant cytotoxicity toward different human cancer cells, from which, a basic structure-activity relationship might be able to obtain. On the basis of these progresses, we believe that this review may provide new ideas for generating potent anticancer compounds bearing the same pharmacophores derived from those macrocyclic molecules.
非酸是大环非替康的一个亚基，含有四个不对称中心，分子式为 C10H18O3。自 1955 年以来，由于其具有各种生物活性和具有挑战性的结构特征，非酸及其衍生物引起了科学家们的极大关注。这些化合物具有显著的抗菌、杀虫和杀螨活性，以及促进植物生长的作用。然而，这些化合物在抗癌活性方面的研究有限。值得注意的是，一些非酸的衍生物对不同的人类癌细胞表现出显著的细胞毒性，从中可以获得基本的构效关系。在此基础上，我们相信这篇综述可能为生成具有相同药效团的有效抗癌化合物提供新的思路，这些药效团来自于这些大环分子。
