细胞衰老与载脂蛋白 E4：在阿尔茨海默病中的作用。

Cellular Senescence and ApoE4: Their Repercussions in Alzheimer's Disease.

机构信息

Posgrado en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico (UACM), Apdo, Postal 03100, Ciudad de Mexico, Mexico.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Apdo, Postal 04510, Ciudad de Mexico, Mexico.

出版信息

CNS Neurol Disord Drug Targets. 2021;20(9):778-785. doi: 10.2174/1871527320666210628102721.

DOI:10.2174/1871527320666210628102721

PMID:34182916

Abstract

Alzheimer's Disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ε4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implications of cellular senescence and the ApoE variants in AD. Molecular studies of these risk factors for AD may hence be pivotal to define new biomarkers and novel therapeutic strategies for this neurodegenerative pathology.

摘要

阿尔茨海默病（AD）的特征是由于神经退行性变导致的进行性记忆丧失，这种退行性变主要发生在衰老过程中。衰老细胞的积累与衰老有关。此外，载脂蛋白 E 变体 ε4 的表达是 AD 的一个关键危险因素。衰老过程中发生的一些事件，如促炎分子的分泌、代谢和表观遗传变化，以及 ApoE4 的检测，可能会加速 AD 的进展。在这里，我们讨论了细胞衰老和 ApoE 变体在 AD 中的意义。因此，对这些 AD 危险因素的分子研究可能对确定这种神经退行性病变的新生物标志物和新的治疗策略至关重要。