Department of Psychology, University of Stirling Faculty of Natural Sciences, Stirling, UK.
Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina Faculty of Medicine and Surgery, Messina, Italy.
BMJ Open. 2021 Jun 28;11(6):e046452. doi: 10.1136/bmjopen-2020-046452.
Sport-related repetitive subconcussive head impacts (RSHIs) are increasingly thought to be associated with adverse long-term outcomes. However, owing to potentially subtle effects, accurate assessment of harm to the brain as a consequence of RSHI is a major challenge and an unmet need. Several studies suggest that biofluid markers can be valuable objective tools to aid the diagnosis and injury characterisation and help in medical decision-making. Still, by and large, the results have been limited, heterogeneous and inconsistent. The main aims of this scoping review are therefore (1) to systematically examine the extent, nature and quality of available evidence from studies investigating effects of RSHI on fluid biomarkers and (2) to formulate guidelines and identify gaps with the aim to inform future clinical studies and the development of research priorities.
We will use a comprehensive search strategy to retrieve all available and relevant articles in the literature. The following electronic databases will be systematically searched: MEDLINE (EBSCO host; from 1809 to 2020); Scopus (from 1788 to 2020); SPORTDiscus (from 1892 to 2020); CINAHL Complete (from 1937 to 2020); PsycINFO (from 1887 to 2020); Cochrane Library (to 2020); OpenGrey (to 2020); ClinicalTrials.gov (to 2020) and WHO International Clinical Trials Registry Platform (to 2020). We will consider primarily biomedical studies evaluating the biofluid markers following RSHI. Two independent reviewers will screen articles for inclusion using predefined eligibility criteria and extract data of retained articles. Disagreements will be resolved through consensus or arbitrated by a third reviewer if necessary. Data will be reported qualitatively given the heterogeneity of the included studies. In synthesising the evidence, we will structure results by markers, sample types, outcomes, sport and timepoints.
Ethics approval is not required. We will submit results for peer-review publication, and present at relevant conferences.
与运动相关的重复性轻微脑震荡（RSHI）越来越被认为与不良的长期后果有关。然而，由于潜在的细微影响，准确评估 RSHI 对大脑造成的伤害是一个主要挑战，也是一个尚未满足的需求。几项研究表明，生物流体标志物可以作为有价值的客观工具，有助于诊断和损伤特征描述，并有助于医疗决策。尽管如此，总的来说，结果仍然有限、不一致。因此，本次范围界定综述的主要目的是：（1）系统地检查研究 RSHI 对流体生物标志物影响的现有证据的范围、性质和质量；（2）制定指导方针并确定差距，以告知未来的临床研究和制定研究重点。
我们将使用全面的搜索策略检索文献中所有可用且相关的文章。将系统地检索以下电子数据库：MEDLINE（EBSCO 主机；从 1809 年到 2020 年）；Scopus（从 1788 年到 2020 年）；SPORTDiscus（从 1892 年到 2020 年）；CINAHL Complete（从 1937 年到 2020 年）；PsycINFO（从 1887 年到 2020 年）；Cochrane Library（到 2020 年）；OpenGrey（到 2020 年）；ClinicalTrials.gov（到 2020 年）和世界卫生组织国际临床试验注册平台（到 2020 年）。我们将主要考虑评估 RSHI 后生物流体标志物的生物医学研究。两名独立的审查员将使用预设的纳入标准筛选文章，并提取保留文章的数据。如有分歧，将通过协商解决，如果需要，将由第三名审查员仲裁。鉴于纳入研究的异质性，将以定性方式报告数据。在综合证据时，我们将根据标志物、样本类型、结果、运动和时间点来组织结果。
不需要伦理批准。我们将提交同行评审的出版结果，并在相关会议上展示。
