2-12 岁出现癫痫发作的儿童的抗癫痫药物水平：一项单中心横断面研究。
Antiseizure Drug Levels in Children Aged 2-12 Years Presenting With Breakthrough Seizures: A Single Center Cross-sectional Study.
机构信息
Department of Pediatrics, UCMS and GTB Hospital, Delhi. Correspondence to: Dr. Rajan Garg, Department of Pediatrics, University College of Medical Science and GTB Hospital, Delhi110095.
Department of Pediatrics, UCMS and GTB Hospital, Delhi.
出版信息
Indian Pediatr. 2021 Sep 15;58(9):850-852. Epub 2021 Jun 28.
OBJECTIVES
To study the antiseizure drug levels and associated factors in children with breakthrough seizures.
METHODS
This cross-sectional study conducted at a public hospital from November, 2017 to April, 2019, included 145 children with epilepsy aged 2 to 12 years presenting with breakthrough seizure. Antiseizure drug levels were measured, and the levels were categorized as within, below, and above the reference range.
RESULTS
Children with epilepsy receiving sodium valproate, phenytoin and carbamazepine were 111 (73%), 31 (20.4%) and 10 (6.6%), respectively, of which 7 were receiving multiple antiseizure drugs. Drug levels below the reference range were found in 64 (44.1%), within the reference range in 70 (48.3%), and the above reference range in 11 (7.6%) children.
CONCLUSIONS
Nearly half the children with breakthrough seizures had sub-therapeutic levels, especially those on phenytoin therapy. Drug levels in below therapeutic range were not associated with occurrence of breakthrough seizures.
目的
研究伴有发作突破的儿童的抗癫痫药物（AED）血药浓度及其相关因素。
方法
这是一项于 2017 年 11 月至 2019 年 4 月在一家公立医院进行的横断面研究，共纳入 145 例年龄为 2 至 12 岁、伴有发作突破的癫痫儿童。检测了 AED 血药浓度，并将浓度分为参考范围内、低于参考范围和高于参考范围。
结果
接受丙戊酸钠、苯妥英钠和卡马西平治疗的癫痫儿童分别为 111 例（73%）、31 例（20.4%）和 10 例（6.6%），其中 7 例接受了多种 AED 治疗。64 例（44.1%）儿童的血药浓度低于参考范围，70 例（48.3%）在参考范围内，11 例（7.6%）高于参考范围。
结论
近一半伴有发作突破的儿童的 AED 血药浓度处于治疗范围以下，尤其是接受苯妥英钠治疗的儿童。治疗范围以下的血药浓度与发作突破的发生无关。
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