Department of Diabetes, Endocrinology & Metabolism, University of Nebraska Medical Center.
Creighton University Osteoporosis Research Center, Omaha, Nebraska, USA.
Curr Opin Endocrinol Diabetes Obes. 2021 Aug 1;28(4):371-376. doi: 10.1097/MED.0000000000000644.
This article reviews the current state of research in type 1 diabetes and bone, focusing on human bone turnover markers and histomorphometry.
Bone turnover markers have been used for decades to document static bone turnover status in a variety of diseases but especially in diabetes. Two new studies focus on dynamic testing conditions to examine the acute effects of insulin and exercise on bone turnover. Publications of human bone histomorphometry in type 1 diabetes are few but there are several new studies currently underway.
Here, we review the most recent literature on human bone turnover markers and histomorphometry. Low bone turnover is thought to be a major underlying factor in bone fragility in T1DM. Further studies in human transilial bone biopsies will be helpful in determining the mechanisms.
本文回顾了 1 型糖尿病与骨相关的研究现状，重点关注了人类骨转换标志物和组织形态计量学。
数十年来，骨转换标志物一直被用于记录各种疾病，尤其是糖尿病患者的静态骨转换状态。两项新研究聚焦于动态检测条件，以研究胰岛素和运动对骨转换的急性影响。关于 1 型糖尿病患者的人类骨组织形态计量学的文献很少，但目前有几项新研究正在进行中。
本文回顾了关于人类骨转换标志物和组织形态计量学的最新文献。骨转换率低被认为是 1 型糖尿病患者骨脆弱的一个主要潜在因素。对人类胫骨横向骨活检的进一步研究将有助于确定相关机制。
