Hoffmans M D, Kromhout D, de Lezenne Coulander C
Institute of Social Medicine, University of Leiden, The Netherlands.
J Clin Epidemiol. 1988;41(8):749-56. doi: 10.1016/0895-4356(88)90161-8.
In a non-concurrent cohort study, the data from medical examinations of 78,612 Dutch men at the age of 18 were linked to mortality registrations over a follow-up period of 32 years. Body weight and height, blood pressure, resting pulse rate, education, birth order and a health score were recorded. The average Body Mass Index was 20.8 kg/m2. About 5% of the men were very lean (BMI less than 18) and only about 2% had grade I obesity (BMI greater than 25). During 32 years of follow-up 3642 men died. By means of a logistic regression analysis the impact of Body Mass Index (BMI) at the age of 18 on longevity was investigated. Healthy, well-educated men with a BMI of 19 had a higher rate of survival during the entire follow-up period. A negative effect of a high BMI (greater than 25) was only demonstrable after 20 years of follow-up. Men with a BMI under 18 had an increased mortality risk, which was mainly caused by an impaired health status. The results of this study support the hypothesis that moderately obese young men have an increased mortality risk.
在一项非同期队列研究中，对78612名18岁荷兰男性的医学检查数据与32年随访期内的死亡率登记数据进行了关联。记录了体重、身高、血压、静息脉搏率、教育程度、出生顺序和健康评分。平均体重指数为20.8kg/m²。约5%的男性非常消瘦（体重指数低于18），只有约2%的男性患有I级肥胖（体重指数大于25）。在32年的随访期间，3642名男性死亡。通过逻辑回归分析，研究了18岁时体重指数（BMI）对寿命的影响。体重指数为19的健康、受过良好教育的男性在整个随访期间的生存率较高。高体重指数（大于25）的负面影响直到随访20年后才显现出来。体重指数低于18的男性死亡风险增加，这主要是由健康状况受损所致。本研究结果支持中度肥胖的年轻男性死亡风险增加这一假说。
