Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA, USA.
W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Nat Neurosci. 2021 Aug;24(8):1065-1070. doi: 10.1038/s41593-021-00871-z. Epub 2021 Jun 28.
Hippocampal theta rhythm is a therapeutic target because of its vital role in neuroplasticity, learning and memory. Curiously, theta differs across species. Here we show that theta rhythmicity is greatly amplified when rats run in virtual reality. A novel eta rhythm emerged in the CA1 cell layer, primarily in interneurons. Thus, multisensory experience governs hippocampal rhythms. Virtual reality can be used to boost or control brain rhythms and to alter neural dynamics, wiring and plasticity.
海马体θ节律是神经可塑性、学习和记忆的重要靶点。有趣的是，θ节律在不同物种间存在差异。本研究显示，大鼠在虚拟现实中奔跑时，θ节律会大幅增强。CA1 细胞层出现了一种新型的 η 节律，主要存在于中间神经元中。因此，多感觉经验控制着海马体的节律。虚拟现实可用于增强或控制脑节律，改变神经动力学、连接和可塑性。
