University of Iowa, Iowa City, IA, USA.
MI Laboratories, North Liberty, IA 52317, USA.
Future Microbiol. 2021 Jul;16:765-768. doi: 10.2217/fmb-2021-0086. Epub 2021 Jun 29.
Life-threatening infections can be caused by a fungus called (shortened to ) that is found in the hospital environment. This study looked at how well different drugs could treat infection. Samples were collected from 36 people who had infection. The samples were treated with single drugs and in combination. We found that the main drug types did not work on most samples. Genetic differences we found in the samples could explain why the main drugs did not work. However, a drug called isavuconazole worked on almost all samples. We also found that a drug called anidulafungin worked better against when it was combined with either isavuconazole or another drug called voriconazole.
（缩写为 ）是一种存在于医院环境中的真菌，可引起危及生命的感染。本研究旨在探究不同药物治疗 感染的效果。研究采集了 36 名 感染患者的样本，分别用单一药物和联合用药进行处理。结果发现，大多数样本对主要药物类型没有反应。我们在 样本中发现的基因差异可以解释主要药物无效的原因。然而，一种名为伊曲康唑的药物几乎对所有样本都有效。我们还发现，当与伊曲康唑或另一种名为伏立康唑的药物联合使用时，棘白菌素类药物阿尼芬净对抗 的效果更好。
