Antifungal drugs work together to treat germs causing fungal infections.

Life-threatening infections can be caused by a fungus called (shortened to ) that is found in the hospital environment. This study looked at how well different drugs could treat infection. Samples were collected from 36 people who had infection. The samples were treated with single drugs and in combination. We found that the main drug types did not work on most samples. Genetic differences we found in the samples could explain why the main drugs did not work. However, a drug called isavuconazole worked on almost all samples. We also found that a drug called anidulafungin worked better against when it was combined with either isavuconazole or another drug called voriconazole.