Reproductive Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321#, Nanjing210008, People's Republic of China.
Center for Molecular Reproductive Medicine, Nanjing University, Nanjing210008, People's Republic of China.
Zygote. 2022 Feb;30(1):132-137. doi: 10.1017/S0967199421000435. Epub 2021 Jun 28.
This study analyzed the effects of the day of trophectoderm (TE) biopsy and blastocyst grade on clinical and neonatal outcomes. The results showed that the implantation and live birth rates of day 5 (D5) TE biopsy were significantly higher compared with those of D6 TE biopsy. The miscarriage rate of the former was lower than that of the latter, but there was no statistically significant difference. Higher quality blastocysts can achieve better implantation and live birth rates. Among good quality blastocysts, the implantation and live birth rates of D5 and D6 TE biopsy were not significantly different. Among fair quality and poor quality blastocysts, the implantation and live birth rates of D5 TE biopsy were significantly higher compared with those of D6 TE biopsy. Neither blastocyst grade nor the day of TE biopsy significantly affected the miscarriage rate. Neonatal outcomes, including newborn sex, gestational age, preterm birth, birth weight and low birth weight in the D5 and D6 TE biopsies were not significantly different. Both blastocyst grade and the day of TE biopsy must be considered at the same time when performing preimplantation genetic testing-frozen embryo transfer.
本研究分析了滋养外胚层（TE）活检日和囊胚等级对临床和新生儿结局的影响。结果表明，第 5 天（D5）TE 活检的着床率和活产率明显高于第 6 天（D6）TE 活检，前者的流产率低于后者，但差异无统计学意义。高质量的囊胚可以获得更好的着床率和活产率。在优质囊胚中，D5 和 D6 TE 活检的着床率和活产率无显著差异。在中质量和低质量囊胚中，D5 TE 活检的着床率和活产率明显高于 D6 TE 活检。囊胚等级和 TE 活检日期均不显著影响流产率。D5 和 D6 TE 活检的新生儿结局，包括新生儿性别、胎龄、早产、出生体重和低出生体重，均无显著差异。在进行胚胎植入前遗传学检测-冷冻胚胎移植时，必须同时考虑囊胚等级和 TE 活检日期。
