College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, P. R. China.
School of Engineering, China Pharmaceutical University, No. 639 Longmian Avenue, Nanjing, 211198, P. R. China.
Chemistry. 2021 Sep 9;27(51):13024-13028. doi: 10.1002/chem.202101527. Epub 2021 Aug 5.
A novel electrochemical protocol for the oxidative cleavage of indoles has been developed, which offers a simple way to access synthetically useful anthranilic acid derivatives. In undivided cells, a wide variety of indoles and alcohol compounds are examined to afford amide ester aromatics without using extra oxidants and stoichiometric metal catalysts, which avoids the formation of undesired by-products and exhibits high atom economy. The products we described in this perspective represent a synthetic intermediate in numerous drug molecules and industrial chemical reagents and remarkably show potential application in the future.
一种新颖的电化学方法被开发出来，用于吲哚的氧化裂解，为合成有用的邻氨基苯甲酸衍生物提供了一种简单的方法。在未分隔的电池中，广泛的吲哚和醇化合物被检测到，以提供酰胺酯芳烃，而不使用额外的氧化剂和化学计量的金属催化剂，避免了不需要的副产物的形成，并表现出高的原子经济性。我们在这篇综述中描述的产物代表了许多药物分子和工业化学试剂的合成中间体，并且在未来具有显著的应用潜力。
