Department of Obstetrics and Gynecology, Distinct Healthcare, Shenzhen, P. R. China.
Department of Obstetrics and Gynecology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, P. R. China.
Gynecol Endocrinol. 2022 Jan;38(1):10-15. doi: 10.1080/09513590.2021.1940932. Epub 2021 Jun 29.
We aimed to investigate the potential predictive efficacy of triglyceride-glucose (T/Gly) index for gestational diabetes mellitus (GDM) in a systematic review and meta-analysis.
Cohort studies demonstrating the association between T/Gly index measured at the first trimester or before pregnancy and the subsequent incidence of GDM were identified by search of PubMed, Embase, China National Knowledge Infrastructure, and WanFang databases. A random-effect model incorporating the heterogeneity was applied to pool the results. Five cohort studies including 382,213 women were included in this meta-analysis.
Compared to those with the lowest category of T/Gly index, women with the highest category of T/Gly index were independently associated with higher risk of subsequent GDM (odds ratio [OR]: 2.52, 95% confidence interval [CI]: 1.33 ∼ 4.67, =65%, =.004) after adjustment of potential confounding factors including age, body mass index, and family history of diabetes. The association was stronger in prospective cohort studies than retrospective cohort studies ( for subgroup difference=.007), and a significant association was detected in Asian women (OR: 3.30, 95% CI: 1.50-7.28, =.003), but not in non-Asian women (OR: 0.96, 95% CI: 0.35-2.63, =.94).
Higher T/Gly index may independently predict the risk of GDM in Asian women.
我们旨在通过系统评价和荟萃分析研究三酰甘油-葡萄糖（T/Gly）指数对妊娠糖尿病（GDM）的潜在预测效能。
通过检索 PubMed、Embase、中国知网和万方数据库，确定了在孕早期或妊娠前测量 T/Gly 指数与随后发生 GDM 之间存在关联的队列研究。应用包含异质性的随机效应模型对结果进行合并。本荟萃分析共纳入了 5 项队列研究，共计 382213 名女性。
与 T/Gly 指数最低组相比，最高组女性发生 GDM 的风险独立升高（比值比 [OR]：2.52，95%置信区间 [CI]：1.334.67， =65%， =.004），校正年龄、体重指数和糖尿病家族史等潜在混杂因素后仍如此。与回顾性队列研究相比，前瞻性队列研究的相关性更强（ for 亚组差异=.007），且在亚洲女性中存在显著相关性（OR：3.30，95% CI：1.507.28， =.003），而非亚洲女性中则无相关性（OR：0.96，95% CI：0.35~2.63， =.94）。
较高的 T/Gly 指数可能独立预测亚洲女性发生 GDM 的风险。
