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Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia.英克西兰用于治疗杂合子家族性高胆固醇血症。
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Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.两项降低 LDL 胆固醇的依洛尤单抗 3 期临床试验。
N Engl J Med. 2020 Apr 16;382(16):1507-1519. doi: 10.1056/NEJMoa1912387. Epub 2020 Mar 18.
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Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial.贝匹地酸对比安慰剂联合最大耐受他汀类药物治疗对心血管疾病高危患者的低密度脂蛋白胆固醇的影响:CLEAR Wisdom 随机临床试验。
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Bempedoic acid plus ezetimibe fixed-dose combination in patients with hypercholesterolemia and high CVD risk treated with maximally tolerated statin therapy.贝特帕酸联合依折麦布固定剂量复方制剂在最大耐受他汀治疗的高胆固醇血症和高 CVD 风险患者中的应用。
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Familial Hypercholesterolemia Among Young Adults With Myocardial Infarction.青年心肌梗死患者中的家族性高胆固醇血症。
J Am Coll Cardiol. 2019 May 21;73(19):2439-2450. doi: 10.1016/j.jacc.2019.02.059.
7
Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance.贝匹地酸治疗高胆固醇血症及他汀类药物不耐受患者的疗效和安全性。
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Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol.贝匹地酸降低 LDL 胆固醇的安全性和有效性。
N Engl J Med. 2019 Mar 14;380(11):1022-1032. doi: 10.1056/NEJMoa1803917.
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2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2018 年美国心脏病学会/美国心脏协会/美国心血管血管造影和介入学会/美国预防、物理治疗和康复医师学会/美国糖尿病协会/美国老年学会/美国药学会/美国医师协会/美国生理学会/北美介入放射学会/美国国家脂质协会/美国临床内分泌医师协会胆固醇管理指南:美国心脏病学会/美国心脏协会临床实践指南工作组的报告。
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Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study.在不能耐受他汀类药物的高胆固醇血症患者中,添加苯扎贝特酸与依折麦布联合治疗的疗效和安全性:一项随机、安慰剂对照研究。
Atherosclerosis. 2018 Oct;277:195-203. doi: 10.1016/j.atherosclerosis.2018.06.002. Epub 2018 Jun 12.

贝匹地酸和依洛尤单抗在杂合子家族性高胆固醇血症和 ASCVD 二级预防中的有效性和价值。

The effectiveness and value of bempedoic acid and inclisiran for heterozygous familial hypercholesterolemia and secondary prevention of ASCVD.

机构信息

Institute for Clinical and Economic Review, Boston, MA.

Division of General Internal Medicine and Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco.

出版信息

J Manag Care Spec Pharm. 2021 Jul;27(7):961-966. doi: 10.18553/jmcp.2021.27.7.961.

DOI:10.18553/jmcp.2021.27.7.961
PMID:34185561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10391137/
Abstract

Funding for this summary was contributed by Arnold Ventures, California Health Care Foundation, The Donaghue Foundation, Harvard Pilgrim Health Care, and Kaiser Foundation Health Plan to the Institute for Clinical and Economic Review (ICER), an independent organization that evaluates the evidence on the value of health care interventions. ICER's annual policy summit is supported by dues from AbbVie, Aetna, America's Health Insurance Plans, Anthem, Alnylam, AstraZeneca, Biogen, Blue Shield of CA, Boehringer-Ingelheim, Cambia Health Services, CVS, Editas, Evolve Pharmacy, Express Scripts, Genentech/Roche, GlaxoSmithKline, Harvard Pilgrim, Health Care Service Corporation, HealthFirst, Health Partners, Humana, Johnson & Johnson (Janssen), Kaiser Permanente, LEO Pharma, Mallinckrodt, Merck, Novartis, National Pharmaceutical Council, Pfizer, Premera, Prime Therapeutics, Regeneron, Sanofi, Spark Therapeutics, uniQure, and United Healthcare. Agboola, McKenna, and Pearson are employed by ICER. Lin and Kazi received funding from ICER for work on this report.

摘要

本摘要的资助由 Arnold Ventures、加州医疗保健基金会、Donaghue 基金会、哈佛朝圣者健康保险和 Kaiser 基金会健康计划提供给临床与经济评价研究所(ICER),这是一个独立评估医疗保健干预措施价值的证据的组织。ICER 的年度政策峰会得到了 AbbVie、Aetna、美国健康保险计划、Anthem、Alnylam、阿斯利康、Biogen、加州蓝盾、勃林格殷格翰、Cambia 健康服务、CVS、Editas、Evolve Pharmacy、Express Scripts、Genentech/Roche、葛兰素史克、哈佛朝圣者、医疗保健服务公司、HealthFirst、Health Partners、Humana、强生(杨森)、Kaiser 永久、LEO 制药、美纳里克斯、默克、诺华、国家制药理事会、辉瑞、Premera、Prime Therapeutics、Regeneron、赛诺菲、Spark Therapeutics、uniQure 和 United Healthcare 的会费支持。Agboola、McKenna 和 Pearson 受雇于 ICER。Lin 和 Kazi 因参与本报告的工作而从 ICER 获得了资金。