Service de Pédiatrie, CHU d'Amiens, Amiens F-80000, France; INFINITE - INSERM U1286, Pôle Recherche 5ème étage Epicenter Est, CHU de Lille, Institute for Translational Research in Inflammation, Université de Lille, 1 Place Verdun, Lille F-59045, France.
Service de Gastroentérologie Pédiatrique, CHU de Rennes, Rennes F-35033, France.
Dig Liver Dis. 2021 Oct;53(10):1268-1275. doi: 10.1016/j.dld.2021.05.034. Epub 2021 Jun 27.
Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission.
To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD).
Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed.
Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents.
Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL.
缓解期炎症性肠病（IBD）患儿常出现慢性腹痛。
评估缓解期 IBD 患儿功能性腹痛障碍（IBD-FAPD）的患病率及其相关因素。
从全国性 IBD 网络中招募 IBD 病史＞1 年、缓解期≥3 个月的患者。采用 Rome III 问卷标准评估 IBD-FAPD。评估患者或家长报告的结果。
102 例患者中，57 例（56%）为男性，平均年龄（标准差）为 15.0（±2.0）岁，75 例（74%）患有克罗恩病。22 例（22%）患者存在至少一种功能性胃肠疾病，其中 17 例存在至少一种 IBD-FAPD。疾病既往严重程度或接受的治疗与 IBD-FAPD 无显著相关性。有 IBD-FAPD 的患者报告更多疲劳（peds-FACIT-F：35.9±9.8 与 43.0±6.9，p=0.01）和较低的 HR-QoL（IMPACT III：76.5±9.6 与 81.6±9.2，p=0.04），其父母的状态焦虑和特质焦虑评分高于无 FAPD 患者的父母。
IBD-FAPD 的患病率为 17%。IBD-FAPD 与疾病既往严重程度无关，但与疲劳和较低的 HR-QoL 相关。
