多环芳烃与美国成年人肾结石风险：2007 - 2012年美国国家健康与营养检查调查的暴露-反应分析
Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007-2012.
作者信息
Sun Si, Mao Weipu, Tao Shuchun, Zou Xiangyu, Tian Shengwei, Qian Siwei, Yao Chi, Zhang Guangyuan, Chen Ming
机构信息
Department of Urology, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.
Surgical Research Center, Institute of Urology, Southeast University Medical School, Nanjing, 210009, People's Republic of China.
出版信息
Int J Gen Med. 2021 Jun 21;14:2665-2676. doi: 10.2147/IJGM.S319779. eCollection 2021.
BACKGROUND
Polycyclic aromatic hydrocarbons (PAHs) exposure may cause various diseases. However, the association between PAHs exposure and kidney stones remains unclear. The purpose of this study was to examine the relationship between PAHs and the risk of kidney stones in the US population.
METHODS
The study included a total of 30,442 individuals (≥20 years) from the 2007-2012 National Health and Nutrition Examination Survey (NHANES). Nine urinary PAHs were included in this study. Logistic regression and dose-response curves were used to evaluate the association between PAHs and the risk of kidney stones.
RESULTS
We selected 4385 participants. The dose-response curves showed a significant positive association between total PAHs, 2-hydroxynaphthalene, 1-hydroxyphenanthrene, 2-hydroxyphenanthrene, 9-hydroxyfluorene and the risk of kidney stones after adjusting for confounding factors. Compared with the low group, an increased risk of kidney stones was observed in the high group of total PAHs [OR (95% CI), 1.32 (1.06-1.64), P=0.013], 2-hydroxynaphthalene [OR (95% CI), 1.37 (1.10-1.71), P=0.005], 1-hydroxyphenanthrene [OR (95% CI), 1.24 (1.00-1.54), P=0.046] and 9-hydroxyfluorene [OR (95% CI), 1.36 (1.09-1.70), P=0.007].
CONCLUSION
High levels of PAHs were positively associated with the risk of kidney stones in the US population.
背景
多环芳烃（PAHs）暴露可能导致多种疾病。然而，PAHs暴露与肾结石之间的关联仍不明确。本研究的目的是探讨美国人群中PAHs与肾结石风险之间的关系。
方法
本研究纳入了2007 - 2012年国家健康与营养检查调查（NHANES）中总共30442名年龄≥20岁的个体。本研究纳入了九种尿中PAHs。采用逻辑回归和剂量反应曲线来评估PAHs与肾结石风险之间的关联。
结果
我们选取了4385名参与者。在调整混杂因素后，剂量反应曲线显示总PAHs、2 - 羟基萘、1 - 羟基菲、2 - 羟基菲、9 - 羟基芴与肾结石风险之间存在显著正相关。与低暴露组相比，总PAHs高暴露组[比值比（95%置信区间），1.32（1.06 - 1.64），P = 0.013]、2 - 羟基萘高暴露组[比值比（95%置信区间），1.37（1.10 - 1.71），P = 0.005]、1 - 羟基菲高暴露组[比值比（95%置信区间），1.24（1.00 - 1.54），P = 0.046]和9 - 羟基芴高暴露组[比值比（95%置信区间），1.36（1.09 - 1.70），P = 0.007]的肾结石风险增加。
结论
在美国人群中，高水平的PAHs与肾结石风险呈正相关。
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