铜催化烯胺酮C(sp)-N键的膦酰化反应用于立体选择性合成链烯基膦酸酯
Copper-Catalyzed Enaminone C(sp)-N Bond Phosphonation for Stereoselective Synthesis of Alkenylphosphonates.
作者信息
Liu Ting, Wei Li, Zhao Baoli, Liu Yunyun, Wan Jie-Ping
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China.
Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing 312000, People's Republic of China.
出版信息
J Org Chem. 2021 Jul 16;86(14):9861-9868. doi: 10.1021/acs.joc.1c00862. Epub 2021 Jun 30.
A direct enaminone C-N bond coupling functionalization that generates a new C-P bond using dialkyl phosphonate for the efficient and stereoselective synthesis of ()-alkenylphosphonates is reported. The reactions toward target products proceed well with a broad scope, disclosing a valuable new synthetic application of enaminones by the interesting C(sp)-N bond elaboration.
报道了一种直接的烯胺酮C-N键偶联官能团化反应，该反应使用膦酸二烷基酯生成新的C-P键，用于高效立体选择性合成（）-烯基膦酸酯。该反应对目标产物具有良好的适应性，通过有趣的C（sp）-N键修饰揭示了烯胺酮一种有价值的新合成应用。
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