Ratner Cecilia, Shin Jae Hoon, Dwibedi Chinmay, Tremaroli Valentina, Bjerregaard Anette, Hartmann Bolette, Bäckhed Fredrik, Leinninger Gina, Seeley Randy J, Holst Birgitte
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Endocrinology. 2021 Sep 1;162(9). doi: 10.1210/endocr/bqab130.
Neurotensin (NT) is an anorexic gut hormone and neuropeptide that increases in circulation following bariatric surgery in humans and rodents. We sought to determine the contribution of NT to the metabolic efficacy of vertical sleeve gastrectomy (VSG). To explore a potential mechanistic role of NT in VSG, we performed sham or VSG surgeries in diet-induced obese NT receptor 1 (NTSR1) wild-type and knockout (ko) mice and compared their weight and fat mass loss, glucose tolerance, food intake, and food preference after surgery. NTSR1 ko mice had reduced initial anorexia and body fat loss. Additionally, NTSR1 ko mice had an attenuated reduction in fat preference following VSG. Results from this study suggest that NTSR1 signaling contributes to the potent effect of VSG to initially reduce food intake following VSG surgeries and potentially also on the effects on macronutrient selection induced by VSG. However, maintenance of long-term weight loss after VSG requires signals in addition to NT.
神经降压素（NT）是一种厌食性肠道激素和神经肽，在人类和啮齿动物接受减肥手术后，其循环水平会升高。我们试图确定NT对垂直袖状胃切除术（VSG）代谢效果的作用。为了探究NT在VSG中的潜在机制作用，我们对饮食诱导肥胖的神经降压素受体1（NTSR1）野生型和敲除（ko）小鼠进行了假手术或VSG手术，并比较了它们术后的体重和脂肪量减少情况、葡萄糖耐量、食物摄入量和食物偏好。NTSR1敲除小鼠的初始厌食和体脂减少情况有所减轻。此外，NTSR1敲除小鼠在VSG后对脂肪偏好的降低也有所减弱。这项研究的结果表明，NTSR1信号传导有助于VSG在术后最初减少食物摄入量的强效作用，并且可能也有助于VSG对宏量营养素选择的影响。然而，VSG术后长期体重减轻的维持除了NT之外还需要其他信号。
