Department of Surgery, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.
Department of Human Health and Medical Sciences, Kochi Medical School, Nankoku, Kochi, Japan.
Int J Clin Oncol. 2021 Oct;26(10):1864-1870. doi: 10.1007/s10147-021-01978-w. Epub 2021 Jun 30.
Zinc is an essential dietary component for humans and the second most prevalent trace element; however, serum zinc levels after gastrectomy have not been fully elucidated. This study aimed to evaluate the correlation between clinicopathologic features and serum zinc levels in patients who underwent gastrectomy for gastric cancer.
The study enrolled 617 patients who underwent gastrectomy for gastric cancer at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level < 80 μg/dL.
The median zinc level of the 617 patients was 73 μg/dL (range, 31-144 μg/dL), and serum zinc deficiency was present in 68.6% of patients. Median age was significantly higher in the zinc low level group than in the normal group (69 vs. 66 years, P < 0.001). Albumin was significantly lower in the zinc low level group than in the normal group (3.9 vs. 4.2 g/dL, P < 0.001). C-reactive protein level was significantly higher in the zinc low level group than in the normal group (0.12 vs. 0.10 mg/dL, P = 0.014). The median serum zinc level was significantly lower in the patients who received chemotherapy after gastrectomy than in those who were not received chemotherapy (72 vs. 76 μg/dL, P < 0.001). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.505, P = 0.044). Multivariate analysis showed that serum albumin level was significantly associated with serum zinc level (β = 0.489, P < 0.001).
Serum zinc deficiency was found in 68.6% of postoperative patients who underwent gastrectomy for gastric cancer, which was highly correlated with serum albumin.
锌是人体必需的膳食成分和第二大常见微量元素，但胃切除术后的血清锌水平尚未完全阐明。本研究旨在评估接受胃癌胃切除术患者的临床病理特征与血清锌水平之间的相关性。
本研究纳入了在高知医科大学接受胃癌胃切除术的 617 名患者。获取临床数据，以调查包括营养指标和血清锌水平在内的临床病理特征之间的相关性。将血清锌缺乏定义为血清锌水平<80μg/dL。
617 名患者的中位锌水平为 73μg/dL（范围为 31-144μg/dL），其中 68.6%的患者存在血清锌缺乏。低锌水平组的中位年龄明显高于正常组（69 岁比 66 岁，P<0.001）。低锌水平组的白蛋白明显低于正常组（3.9 克/分升比 4.2 克/分升，P<0.001）。低锌水平组的 C 反应蛋白水平明显高于正常组（0.12 毫克/分升比 0.10 毫克/分升，P=0.014）。接受胃切除术后化疗的患者的中位血清锌水平明显低于未接受化疗的患者（72 微克/分升比 76 微克/分升，P<0.001）。血清锌水平与血清白蛋白呈显著正相关（r=0.505，P=0.044）。多变量分析显示，血清白蛋白水平与血清锌水平显著相关（β=0.489，P<0.001）。
接受胃癌胃切除术的术后患者中，有 68.6%存在血清锌缺乏，与血清白蛋白高度相关。
