Nobori Chihoko, Matsumoto Ippei, Nakano Masaya, Ami Katsuya, Yoshida Yuta, Lee Dongha, Murase Takaaki, Kamei Keiko, Takebe Atsushi, Nakai Takuya, Takeyama Yoshifumi
Department of Surgery, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama, Osaka, 589-8511, Japan.
Surg Today. 2025 Apr;55(4):552-559. doi: 10.1007/s00595-024-02935-6. Epub 2024 Sep 2.
To clarify the prevalence, risk factors, and clinical implications associated with zinc deficiency in patients undergoing pancreatic surgery.
The serum zinc levels were measured in 329 patients post-pancreatic surgery between January and April 2021. The postoperative serum zinc levels and clinicopathological variables were retrospectively analyzed.
The median serum zinc level was 73 µg/dL (33-218). Zinc deficiency (zinc level < 60 µg/dL) was observed in 52 patients (16%). A total of 329 patients were classified into zinc-deficient (n = 52) and non-deficient (zinc ≥ 60 µg/dL, n = 277) groups. A univariate analysis revealed significant differences in sex, postoperative body mass index, serum albumin, total cholesterol, creatinine, aspartate aminotransferase (AST), HbA1c levels, diabetes, surgical procedures, and operative blood loss. According to a multivariate analysis, male sex [odds ratio (OR) 3.70; 95% confidence interval (CI) 1.67-8.20; p = 0.001], postoperative serum albumin levels < 3.9 g/dL (OR 6.39; 95% CI 3.30-12.37; p < 0.001), postoperative serum AST ≥ 51 U/L (OR, 4.6; 95% CI 0.07-0.29; p < 0.001), and total pancreatectomy (OR 3.68; 95% CI 1.37-9.85; p = 0.009) were found to be independent predictors of zinc deficiency after pancreatic surgery.
Zinc deficiency frequently occurs in patients undergoing pancreatic surgery. Lower postoperative zinc levels could be linked to sex, the serum albumin and AST levels, and surgery type.
明确胰腺手术患者锌缺乏的患病率、危险因素及临床意义。
对2021年1月至4月间329例胰腺手术后患者的血清锌水平进行测定。对术后血清锌水平及临床病理变量进行回顾性分析。
血清锌水平中位数为73µg/dL（33 - 218）。52例患者（16%）出现锌缺乏（锌水平<60µg/dL）。329例患者分为锌缺乏组（n = 52）和非缺乏组（锌≥60µg/dL，n = 277）。单因素分析显示，性别、术后体重指数、血清白蛋白、总胆固醇、肌酐、天冬氨酸转氨酶（AST）、糖化血红蛋白水平、糖尿病、手术方式及术中失血量存在显著差异。多因素分析显示，男性[比值比（OR）3.70；95%置信区间（CI）1.67 - 8.20；p = 0.001]、术后血清白蛋白水平<3.9g/dL（OR 6.39；95%CI 3.30 - 12.37；p < 0.001）、术后血清AST≥51 U/L（OR 4.6；95%CI 0.07 - 0.29；p < 0.001）及全胰切除术（OR 3.68；95%CI 1.37 - 9.85；p = 0.009）是胰腺手术后锌缺乏的独立预测因素。
胰腺手术患者常发生锌缺乏。术后锌水平降低可能与性别血清白蛋白和AST水平及手术类型有关。
