Alvarez-Buylla A, Nottebohm F
Rockefeller University, New York, New York 10021.
Nature. 1988 Sep 22;335(6188):353-4. doi: 10.1038/335353a0.
Neurons are born in the ventricular walls of the vertebrate central nervous system. From there, the young neurons migrate to their final destinations, where differentiation occurs. Neuronal migration has been described during the ontogeny of the avian and mammalian brain. Whereas in mammals most neurogenesis occurs during early development, in the adult avian forebrain wide-spread neurogenesis continues to occur. How do neurons born in adulthood reach their final destination? We report here that small elongated cells, born in the ventricular zone adjacent to the lateral ventricle, differentiate into mature neurons 20-40 days later, after migrating over distances of up to 5 mm. Migration rates are highest (28 micron h-1) when young neurons migrate through regions which are rich in radial glia. The adult vertebrate brain offers unique opportunities for studying factors that regulate neuronal migration, pathfinding and differentiation.
神经元诞生于脊椎动物中枢神经系统的脑室壁。从那里开始，年轻的神经元迁移到它们的最终目的地，并在那里发生分化。在鸟类和哺乳动物大脑的个体发育过程中，神经元迁移现象已被描述。在哺乳动物中，大多数神经发生发生在早期发育阶段，而在成年鸟类前脑中，广泛的神经发生仍在继续。成年后诞生的神经元是如何到达其最终目的地的呢？我们在此报告，在侧脑室附近的脑室区诞生的小而细长的细胞，在迁移长达5毫米的距离后，20 - 40天后分化为成熟神经元。当年轻神经元迁移通过富含放射状胶质细胞的区域时，迁移速度最高（28微米/小时）。成年脊椎动物大脑为研究调节神经元迁移、路径寻找和分化的因素提供了独特的机会。
