Medical University of Varna, Varna, Bulgaria.
St Marina University Hospital, Varna, Bulgaria.
Folia Med (Plovdiv). 2021 Jun 30;63(3):433-437. doi: 10.3897/folmed.53.e56150.
Low grade fibromyxoid sarcoma (LGFMS) is an uncommon variant of fibrosarcoma with high risk of local recurrence, immense metastatic potential and frequently protracted period between tumour presentation and metastasis. This unusual malignancy rarely affects the region of the head and neck which makes cases of laryngeal LGFMS extremely infrequent. To date, LGFMS of the larynx has been scatteredly mentioned in the literature. Neither incidence nor causes and risk factors for laryngeal LGFMS have been clarified so far. To the authors' knowledge, this is the first case report that discusses the clinical course, imaging diagnosis, histopathological evaluation and surgical approach to radiation-induced laryngeal LGFMS.We present a case of a 70-year-old man who developed a LGFMS after previous radiotherapy (RT) for squamous cell carcinoma (SCC) of the larynx. The latency period between the time of radiation exposure and the diagnosis of LGFMS was twenty-seven months. After re-confirming the diagnosis with second biopsy and extensive imaging evaluation the patient was subjected to an open partial resection of the larynx. Owing to the rarity of the tumour, there is no established protocol with follow-up recommendations.This case highlights the importance of considering the RT history of the patient in order to monitor radiotherapy-related complications, including the occurrence of LGFMS.
低度纤维黏液样肉瘤（LGFMS）是一种罕见的纤维肉瘤变体，具有高复发风险、巨大的转移潜力，并且肿瘤表现和转移之间的时间通常较长。这种不常见的恶性肿瘤很少发生在头颈部，因此喉部 LGFMS 极为罕见。迄今为止，喉部 LGFMS 在文献中仅被零星提及。喉部 LGFMS 的发病率、病因和危险因素尚未明确。据作者所知，这是首例讨论放射诱导性喉部 LGFMS 的临床病程、影像学诊断、组织病理学评估和手术方法的病例报告。我们报告了一例 70 岁男性的病例，他在因喉鳞状细胞癌（SCC）接受放射治疗（RT）后发生了 LGFMS。从放射暴露到诊断 LGFMS 的潜伏期为 27 个月。在第二次活检和广泛的影像学评估后再次确认诊断后，患者接受了喉的开放性部分切除术。由于肿瘤罕见，目前尚无既定的治疗方案和随访建议。该病例强调了考虑患者 RT 史的重要性，以便监测放疗相关并发症，包括 LGFMS 的发生。
