Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2021 May 1;24(5):409-418. doi: 10.34172/aim.2021.59.
Depression is a chronic and debilitating psychiatric disorder that affects 300 million people worldwide. Pharmacotherapy is one of the treatments. Due to delay in initiating treatment efficacy and the incomplete response to mono-drug therapy in one-third of patients, new approaches need to be considered. One of the ways to overcome this resistance to treatment and to enhance standard medical practice is to add complementary medicines. We aimed to document research progress from studies on integrative medicine for the treatment of depression. Review of PubMed and Scopus databases on the topic and a personal collection of the relevant publications are the sources for this study. Some of the nutraceuticals and complementary medicines in the treatment of depression will be reviewed. Supplements discussed in this review include S-adenosyl-methionine (SAMe), (Saffron), carnosine, theanine, palmitoylethanolamide (PEA), tryptophan and 5-hydroxytryptophan (5-HTP), gemfibrozil, curcumin (the main active ingredient in turmeric), (St John's wort), (Lavender), and . Despite evidence in favor of the antidepressant effect of several supplements, their efficacy and tolerability should be evaluated and validated by further high-quality studies.
抑郁症是一种慢性且使人虚弱的精神障碍，影响着全球 3 亿人。药物治疗是其中一种治疗方法。由于治疗效果延迟和三分之一的患者对单药治疗反应不完全，需要考虑新的方法。克服这种治疗抵抗和增强标准医学实践的一种方法是添加补充药物。我们旨在记录综合医学治疗抑郁症研究的进展。对有关该主题的 PubMed 和 Scopus 数据库的综述以及个人收集的相关出版物是本研究的来源。本文将对一些用于治疗抑郁症的营养药物和补充药物进行综述。本综述讨论的补充剂包括 S-腺苷甲硫氨酸（SAMe）、藏红花、肌肽、茶氨酸、棕榈酰乙醇酰胺（PEA）、色氨酸和 5-羟色氨酸（5-HTP）、吉非贝齐、姜黄素（姜黄的主要活性成分）、贯叶连翘、薰衣草和缬草根。尽管有证据表明几种补充剂具有抗抑郁作用，但它们的疗效和耐受性应通过进一步的高质量研究进行评估和验证。
