Pertovaara A
Department of Physiology, University of Michigan, Ann Arbor.
Neurosci Lett. 1988 Aug 1;90(3):248-53. doi: 10.1016/0304-3940(88)90197-8.
The innervation area of nociceptive C-fibers in the saphenous nerve of adult rats was detected by the Evans blue technique, in which antidromic excitation of the nociceptive C-fibers causes a visible extravasation of dye in the skin it supplied. One month after cutting the sciatic nerve, the nociceptive C-fibers of the intact saphenous nerve had sprouted to the sciatic area. When capsaicin was locally applied to the nerve trunk to destroy C-fibers of the sciatic nerve, there was no sprouting of nociceptive C-fibers from the saphenous nerve. Thus, myelinated fibers and/or the functionally impaired C-fibers of the sciatic nerve are enough to prevent collateral sprouting of nociceptive C-fibers from the saphenous nerve.
采用伊文思蓝技术检测成年大鼠隐神经中伤害性C纤维的支配区域，在该技术中，伤害性C纤维的逆向兴奋会导致其所支配皮肤中染料的明显外渗。切断坐骨神经1个月后，完整隐神经的伤害性C纤维已向坐骨区域生长。当将辣椒素局部应用于神经干以破坏坐骨神经的C纤维时，隐神经的伤害性C纤维未出现生长。因此，坐骨神经的有髓纤维和/或功能受损的C纤维足以阻止隐神经的伤害性C纤维侧支生长。
