Keyser G F, Boyarsky S, Labay P
Invest Urol. 1975 Nov;13(3):189-95.
The spontaneous activity exhibited in vitro by smooth muscle strips from the urinary bladder of the rabbit under the influence of Urecholine in concentrations from 0.3 to 30 muM has been characterized in terms of three parameters: mean tension, frequency of contraction, and contractile deviation, all obtained by computer an alysis. While mean tension and frequency monotonically increased with concentration, the contractile deviation rose to a peak in the vicinity of 3.0 to 6.0 muM and thereafter decreased. At concentrations less than 10 muM the contractile patterns were almost periodic, while at 10 and 30 muM, the patterns became highly erratic. Histologic examination of a limited number of tissues showed longitudinally oriented muscle bundles with multiple anastomosing.
在浓度为0.3至30μM的乌拉胆碱影响下，兔膀胱平滑肌条在体外表现出的自发活动已根据三个参数进行了表征：平均张力、收缩频率和收缩偏差，所有这些参数均通过计算机分析获得。虽然平均张力和频率随浓度单调增加，但收缩偏差在3.0至6.0μM附近达到峰值，此后下降。在浓度低于10μM时，收缩模式几乎是周期性的，而在10和30μM时，模式变得高度不稳定。对有限数量的组织进行组织学检查显示，有纵向排列的肌束，并有多处吻合。
