Allain P, Leblondel G, Mauras Y
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.
Proc Soc Exp Biol Med. 1988 Sep;188(4):471-3. doi: 10.3181/00379727-188-42762.
Iron (Fe) and aluminum (Al) eliminations in bile were studied in rats after intravenous administration of Fe, Al, deferoxamine mesylate (Desferal, Ciba) (DFA), feroxamine (FeA), and aluminoxamine (AlA) at the dose of 50 mumole/kg body weight. Bile was obtained from the bile duct of anesthetized rats, and the concentrations of Fe and Al in bile were measured by an inductively coupled plasma optical emission spectrometer. The results showed an increase of Fe elimination in bile, from 10 to more than 20 mumole/liter after Fe and also after Al administration; an increase to about 350 mumole/liter after DFA administration; to 250 mumole/liter after FeA administration; and to 100 mumole/liter after AlA administration. Aluminum elimination in bile was increased only after Al and particularly after AlA administration but not after Fe and FeA administration. In conclusion, Al and AlA were able to increase Fe elimination in bile. Thus Al overload observed in hemodialyzed patients may induce an excessive iron loss in bile and partly explain microcytic anemia.
以50微摩尔/千克体重的剂量给大鼠静脉注射铁（Fe）、铝（Al）、去铁胺甲磺酸盐（去铁敏，汽巴公司）（DFA）、铁胺（FeA）和铝胺（AlA）后，研究了胆汁中铁和铝的排泄情况。从麻醉大鼠的胆管获取胆汁，并用电感耦合等离子体发射光谱仪测量胆汁中铁和铝的浓度。结果显示，在给予铁和铝后，胆汁中铁的排泄量增加，从10微摩尔/升增加到20微摩尔/升以上；给予DFA后增加到约350微摩尔/升；给予FeA后增加到250微摩尔/升；给予AlA后增加到100微摩尔/升。仅在给予铝后，尤其是给予AlA后，胆汁中铝的排泄量增加，而给予铁和FeA后则未增加。总之，铝和AlA能够增加胆汁中铁的排泄。因此，血液透析患者中观察到的铝过载可能会导致胆汁中铁过度流失，部分解释了小细胞贫血的原因。
