Bhonsale Satyajeet, Scott Lewis, Ghadiri Mojtaba, Van Impe Jan
BioTeC+, Department of Chemical Engineering, Technology Campus Ghent, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium.
School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UK.
Pharmaceutics. 2021 Jun 23;13(7):937. doi: 10.3390/pharmaceutics13070937.
Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled with discrete element models (DEM) for the particle phase. In this study, we investigate particle dynamics in a 50-mm spiral jet mill through coupled CFD-DEM simulations. The simulations showed that the fluid was significantly decelerated by the presence of the particles in the milling chamber. Furthermore, we study the particle dynamics and collision statistics at two different operating conditions and three different particle loadings. As expected, the particle velocity was affected by both the particle loading and operating pressure. The particles moved slower at low pressures and high loadings. We also found that particle-particle collisions outnumbered particle-wall collisions.
螺旋气流磨在制药行业中无处不在。螺旋气流磨中的破碎和分级是由于流体相和固相之间复杂的相互作用而发生的。对这些相互作用的研究需要使用计算流体动力学(CFD)来研究流体相,并结合离散单元模型(DEM)来研究颗粒相。在本研究中,我们通过耦合CFD-DEM模拟研究了50毫米螺旋气流磨中的颗粒动力学。模拟结果表明,研磨腔内颗粒的存在使流体显著减速。此外,我们研究了两种不同操作条件和三种不同颗粒负载下的颗粒动力学和碰撞统计。正如预期的那样,颗粒速度受颗粒负载和操作压力的影响。在低压和高负载下,颗粒移动较慢。我们还发现颗粒与颗粒之间的碰撞次数超过了颗粒与壁面之间的碰撞次数。