Center for Research in Molecular Medicine and Chronic Diseases, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), 15782 Santiago de Compostela, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Int J Environ Res Public Health. 2021 Jun 25;18(13):6825. doi: 10.3390/ijerph18136825.
Eating behaviour is characterised by a solid balance between homeostatic and hedonic regulatory mechanisms at the central level and highly influenced by peripheral signals. Among these signals, those generated by the gut microbiota have achieved relevance in recent years. Despite this complex regulation, under certain circumstances eating behaviour can be deregulated becoming addictive. Although there is still an ongoing debate about the food addiction concept, studies agree that patients with eating addictive behaviour present similar symptoms to those experienced by drug addicts, by affecting central areas involved in the control of motivated behaviour. In this context, this review tries to summarise the main data regarding the role of the gut microbiome in eating behaviour and how a gut dysbiosis can be responsible for a maladaptive behaviour such as "food addiction".
进食行为的特点是在中枢水平上存在着稳态和享乐调节机制的稳固平衡，并且受到外周信号的强烈影响。在这些信号中，肠道微生物群产生的信号近年来变得相关。尽管存在这种复杂的调节，但在某些情况下，进食行为可能会失调，变得成瘾。尽管关于食物成瘾的概念仍存在争议，但研究一致认为，具有进食成瘾行为的患者表现出与吸毒者相似的症状，因为它们影响了参与控制动机行为的中枢区域。在这种情况下，本综述试图总结关于肠道微生物组在进食行为中的作用以及肠道微生态失调如何导致“食物成瘾”等适应不良行为的主要数据。
