抑制肿瘤微环境中的基质细胞作为清除癌症干细胞的一种治疗策略。
Hampering Stromal Cells in the Tumor Microenvironment as a Therapeutic Strategy to Destem Cancer Stem Cells.
作者信息
Chung Katherine Po Sin, Leung Rainbow Wing Hei, Lee Terence Kin Wah
机构信息
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, China.
出版信息
Cancers (Basel). 2021 Jun 25;13(13):3191. doi: 10.3390/cancers13133191.
Cancer stem cells (CSCs) within the tumor bulk play crucial roles in tumor initiation, recurrence and therapeutic resistance. In addition to intrinsic regulation, a growing body of evidence suggests that the phenotypes of CSCs are also regulated extrinsically by stromal cells in the tumor microenvironment (TME). Here, we discuss the current knowledge of the interplay between stromal cells and cancer cells with a special focus on how stromal cells drive the stemness of cancer cells and immune evasive mechanisms of CSCs. Knowledge gained from the interaction between CSCs and stromal cells will provide a mechanistic basis for the development of novel therapeutic strategies for the treatment of cancers.
肿瘤组织中的癌症干细胞（CSCs）在肿瘤起始、复发和治疗抗性中发挥着关键作用。除了内在调控外，越来越多的证据表明，CSCs的表型也受到肿瘤微环境（TME）中基质细胞的外在调控。在此，我们讨论基质细胞与癌细胞之间相互作用的现有知识，特别关注基质细胞如何驱动癌细胞的干性以及CSCs的免疫逃逸机制。从CSCs与基质细胞之间的相互作用中获得的知识将为开发新型癌症治疗策略提供机制基础。
Zotero 插件