Mohammadi Forogh, Nejatollahi Masoumeh, Sheikhnia Farhad, Ebrahimi Yaser, Mohammadi Mahya, Rashidi Vahid, Alizadeh-Fanalou Shahin, Azizzadeh Bita, Majidinia Maryam
Department of Veterinary, Agriculture Faculty, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
Research Center for High School Students, Education System Zanjan Province, Zanjan, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 14. doi: 10.1007/s00210-024-03719-y.
Chemotherapy remains the cornerstone of cancer treatment; however, its efficacy is frequently compromised by the development of chemoresistance. Multidrug resistance (MDR), characterized by the refractoriness of cancer cells to a wide array of chemotherapeutic agents, presents a significant barrier to achieving successful and sustained cancer remission. One critical factor contributing to this chemoresistance is the overexpression of ATP-binding cassette (ABC) transporters. Furthermore, additional mechanisms, such as the malfunctioning of apoptosis, alterations in DNA repair systems, and resistance mechanisms inherent to cancer stem cells, exacerbate the issue. Intriguingly, microRNAs (miRNAs) have demonstrated potential in modulating chemoresistance by specifically targeting ABC transporters, thereby offering promising new avenues for overcoming drug resistance. This narrative review aims to elucidate the molecular underpinnings of drug resistance, with a particular focus on the roles of ABC transporters and the regulatory influence of miRNAs on these transporters.
化疗仍然是癌症治疗的基石；然而，化疗耐药性的产生常常会削弱其疗效。多药耐药性（MDR）的特征是癌细胞对多种化疗药物具有耐药性，这是实现癌症成功持久缓解的重大障碍。导致这种化疗耐药性的一个关键因素是ATP结合盒（ABC）转运蛋白的过表达。此外，其他机制，如细胞凋亡功能失调、DNA修复系统改变以及癌症干细胞固有的耐药机制，也会加剧这一问题。有趣的是，微小RNA（miRNA）已显示出通过特异性靶向ABC转运蛋白来调节化疗耐药性的潜力，从而为克服耐药性提供了有前景的新途径。这篇叙述性综述旨在阐明耐药性的分子基础，特别关注ABC转运蛋白的作用以及miRNA对这些转运蛋白的调节影响。
