Zhang Kaiwen, Xue Kun, Loh Xian Jun
Department of Biomedical Engineering, College of Engineering, Southern University of Science and Technology (SUSTech), 1088 Xueyuan Avenue, Shenzhen 518055, China.
Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore.
Gels. 2021 Jun 24;7(3):77. doi: 10.3390/gels7030077.
Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol-gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attributed to LCST behavior, micellization, and micelle aggregation of thermogelling polymers. Due to its facile phase conversion properties, thermogels are injectable yet can form an in situ gel in the human body. Thermogels act as a useful platform biomaterial that operates at physiological body temperatures. The purpose of this review is to summarize the recent progress in thermogel research, including investigations on the thermogel gelation mechanism and its applications in drug delivery, 3D cell culture, and tissue engineering. The review also discusses emerging directions in the study of thermogels.
热凝胶也被称为热敏或热响应水凝胶，随着温度升高会发生溶胶-凝胶转变。这种热凝胶化行为是多尺度热响应机制共同作用的结果。从微观到宏观，这些机制可归因于热凝胶化聚合物的最低临界溶液温度（LCST）行为、胶束化和胶束聚集。由于其易于进行相转变的特性，热凝胶可注射，并且能够在人体内形成原位凝胶。热凝胶作为一种有用的平台生物材料，在生理体温下发挥作用。本综述的目的是总结热凝胶研究的最新进展，包括对热凝胶凝胶化机制及其在药物递送、三维细胞培养和组织工程中的应用的研究。该综述还讨论了热凝胶研究中的新兴方向。
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