Puranik Nidhi, Tiwari Shraddha, Kumari Meenakshi, Yadav Shiv Kumar, Dhakal Thakur, Song Minseok
Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of Korea.
Department of Botany, Career Point University, Kota 324005, Rajasthan, India.
J Funct Biomater. 2025 Jul 9;16(7):255. doi: 10.3390/jfb16070255.
Bioactive materials have recently shown potential in nerve repair and regeneration by promoting the growth of new cells, tissue repair, and restoring nerve function. These natural, synthetic, and hybrid materials offer a biomimetic structure, enhance cell attachment, and release bioactive molecules that promote the axonal extension of severed nerves. Scaffold-based preclinical studies have shown promising results on enhancing nerve repair; however, they are limited by the immune response and fabrication, scalability, and cost. Nevertheless, advances in manufacturing, including 3D bioprinting, and other strategies, such as gene editing by CRISPR, will overcome these shortcomings. The opportunity for the development of individualized approaches and specific treatment plans for each patient will also increase the effectiveness of bioactive materials for the treatment of nerve injuries. Combining bioactive materials with the neural interface can develop new reliable therapeutic solutions, particularly for neuroprosthetics. Finally, it is essential to stress a multidisciplinary focus, and future studies are needed to enhance the potential of bioactive materials for patients with nerve injuries and the field of regenerative medicine.
生物活性材料最近通过促进新细胞生长、组织修复和恢复神经功能，在神经修复和再生方面显示出潜力。这些天然、合成和混合材料提供了仿生结构，增强了细胞附着，并释放促进切断神经轴突延伸的生物活性分子。基于支架的临床前研究在增强神经修复方面显示出了有希望的结果；然而，它们受到免疫反应、制造、可扩展性和成本的限制。尽管如此，包括3D生物打印在内的制造技术进步以及其他策略，如CRISPR基因编辑，将克服这些缺点。为每个患者开发个性化方法和特定治疗方案的机会也将提高生物活性材料治疗神经损伤的有效性。将生物活性材料与神经接口相结合可以开发新的可靠治疗方案，特别是用于神经假体。最后，强调多学科重点至关重要，未来需要开展研究以增强生物活性材料对神经损伤患者和再生医学领域的潜力。
