Montaño L M, Selman M, Ponce-Monter H, Vargas M H
Depto. de Fisiología y Farmacología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, México DF.
Res Exp Med (Berl). 1988;188(3):167-73. doi: 10.1007/BF01852317.
It has been demonstrated that the lack of epithelium in healthy airways from different species modifies the reactivity of tracheobronchial smooth muscle. In the present work we have investigated the effect of airway epithelium removal in tracheal chains from guinea pigs sensitized to ovalbumin by inhalatory route and unsensitized animals. We found that in both groups the mechanical removal of airway epithelium produced an increase in the tracheal sensitivity and maximum contractile response to histamine. The greatest responses were observed in epithelium-lacking sensitized tracheas. These findings, at least in vitro, support the idea that the damage of respiratory epithelium plays an important role in modulating the airway reactivity and this is more noteworthy in tracheal chains from previously sensitized guinea pigs.
业已证明，不同物种健康气道中上皮的缺失会改变气管支气管平滑肌的反应性。在本研究中，我们调查了通过吸入途径对卵清蛋白致敏的豚鼠和未致敏动物的气管链中气道上皮去除的影响。我们发现，在两组中，气道上皮的机械去除均导致气管对组胺的敏感性增加以及最大收缩反应增强。在缺乏上皮的致敏气管中观察到最大反应。这些发现，至少在体外，支持了呼吸道上皮损伤在调节气道反应性中起重要作用的观点，并且这在先前致敏的豚鼠的气管链中更为显著。
