Functional Genomics Laboratory, Instituto Nacional de Medicina Genomica, Periferico Sur 4809, Tlalpan, Mexico City 14610, Mexico.
Epigenomics Laboratory, Instituto Nacional de Medicina Genomica, Periferico Sur 4809, Tlalpan, Mexico City 14610, Mexico.
Int J Mol Sci. 2021 Jun 15;22(12):6374. doi: 10.3390/ijms22126374.
Pancreatic ductal adenocarcinoma is one of the deadliest tumors. This neoplasia is characterized by an important cellular and phenotypic heterogeneity. In particular, it has been shown that at least two subtypes can be found: basal-like, which presents stem-like properties, and classical. Cancer stem cells have been isolated and characterized from these tumors, showing their dependance on general and tissue-specific stem transcription factors and signaling pathways. Nevertheless, little is known about their tissue microenvironment and cell non-autonomous regulators, such as long-non-coding RNAs. (lncRNAs). In this review, we summarize the current knowledge about the positive and negative effects of lncRNAs in the stemness phenotype of pancreatic ductal adenocarcinoma cancer (PDAC).
胰腺导管腺癌是最致命的肿瘤之一。这种肿瘤的特点是重要的细胞和表型异质性。特别是，已经表明至少可以发现两种亚型：基底样，具有干细胞样特性，和经典型。已经从这些肿瘤中分离和鉴定出癌症干细胞，表明它们依赖于一般和组织特异性干细胞转录因子和信号通路。然而，关于它们的组织微环境和细胞非自主性调节剂，如长非编码 RNA（lncRNA），知之甚少。在这篇综述中，我们总结了目前关于 lncRNA 在胰腺导管腺癌（PDAC）干细胞表型中的正负作用的知识。
