Natalucci Valentina, Marini Carlo Ferri, Flori Marco, Pietropaolo Francesca, Lucertini Francesco, Annibalini Giosuè, Vallorani Luciana, Sisti Davide, Saltarelli Roberta, Villarini Anna, Monaldi Silvia, Barocci Simone, Catalano Vincenzo, Rocchi Marco Bruno Luigi, Benelli Piero, Stocchi Vilberto, Barbieri Elena, Emili Rita
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.
U.O.C. Cardiologia/UTIC, Ospedale Santa Maria della Misericordia, Area Vasta n.1, 61029 Urbino, Italy.
J Clin Med. 2021 Jun 17;10(12):2678. doi: 10.3390/jcm10122678.
This study aimed to evaluate the cardiometabolic effects of a home-based lifestyle intervention (LI) in breast cancer survivors (BCSs) during the COVID-19 lockdown. In total, 30 BCSs (women; stages 0-II; non-metastatic; aged 53.5 ± 7.6 years; non-physically active; normal left ventricular systolic function) with a risk factor for recurrence underwent a 3-month LI based on nutrition and exercise. Anthropometrics, Mediterranean diet adherence, physical activity level (PAL), cardiorespiratory fitness (O), echocardiographic parameters, heart rate variability (average standard deviation of NN intervals (ASDNN/5 min) and 24 h very- (24 hVLF) and low-frequency (24 hLF)), and metabolic, endocrine, and inflammatory serum biomarkers (glycemia, insulin resistance, progesterone, testosterone, and high-sensitivity C-reactive protein (hs-CRP)) were evaluated before (T0) and after (T1) the LI. After the LI, there were improvements in: body mass index (kg/m: T0 = 26.0 ± 5.0, T1 = 25.5 ± 4.7; = 0.035); diet (Mediet score: T0 = 6.9 ± 2.3, T1 = 8.8 ± 2.2; < 0.001); PAL (MET-min/week: T0 = 647 ± 547, T1 = 1043 ± 564; < 0.001); O (mL·min·kg: T0 = 30.5 ± 5.8, T1 = 33.4 ± 6.8; < 0.001); signs of diastolic dysfunction (participants: T0 = 15, T1 = 10; = 0.007); AS-DNN/5 min (ms: T0 = 50.6 ± 14.4, T1 = 55.3 ± 16.7; = 0.032); 24 hLF (ms: T0 = 589 ± 391, T1 = 732 ± 542; = 0.014); glycemia (mg/dL: T0 = 100.8 ± 11.4, T1 = 91.7 ± 11.0; < 0.001); insulin resistance (HOMA-IR score: T0 = 2.07 ± 1.54, T1 = 1.53 ± 1.11; = 0.005); testosterone (ng/mL: T0 = 0.34 ± 0.27, T1 = 0.24 ± 0.20; = 0.003); hs-CRP (mg/L: T0 = 2.18 ± 2.14, T1 = 1.75 ± 1.74; = 0.027). The other parameters did not change. Despite the home-confinement, LI based on exercise and nutrition improved cardiometabolic health in BCSs.
本研究旨在评估在新冠疫情封锁期间，居家生活方式干预（LI）对乳腺癌幸存者（BCS）心脏代谢的影响。共有30名有复发风险因素的BCS（女性；0-II期；非转移性；年龄53.5±7.6岁；非体力活动；左心室收缩功能正常）接受了为期3个月基于营养和运动的LI。在LI前（T0）和后（T1）评估了人体测量学指标、地中海饮食依从性、身体活动水平（PAL）、心肺适能（O）、超声心动图参数、心率变异性（NN间期平均标准差（ASDNN/5分钟）以及24小时超低频（24 hVLF）和低频（24 hLF）），以及代谢、内分泌和炎症血清生物标志物（血糖、胰岛素抵抗、孕酮、睾酮和高敏C反应蛋白（hs-CRP））。LI后，以下指标得到改善：体重指数（kg/m²：T0 = 26.0±5.0，T1 = 25.5±4.7；P = 0.035）；饮食（地中海饮食评分：T0 = 6.9±2.3，T1 = 8.8±2.2；P < 0.001）；PAL（代谢当量-分钟/周：T0 = 647±547，T1 = 1043±564；P < 0.001）；O（mL·min·kg：T0 = 30.5±5.8，T1 = 33.4±6.8；P < 0.001）；舒张功能障碍体征（参与者：T0 = 15，T1 = 10；P = 0.007）；AS-DNN/5分钟（毫秒：T0 = 50.6±14.4，T1 = 55.3±16.7；P = 0.032）；24 hLF（毫秒：T0 = 589±391，T1 = 732±542；P = 0.014）；血糖（mg/dL：T0 = 100.8±11.4，T1 = 91.7±11.0；P < 0.001）；胰岛素抵抗（HOMA-IR评分：T0 = 2.07±1.54，T1 = 1.53±1.11；P = 0.005）；睾酮（ng/mL：T0 = 0.34±0.27，T1 = 0.24±0.20；P = 0.003）；hs-CRP（mg/L：T0 = 2.18±2.14，T1 = 1.75±1.74；P = 0.027）。其他参数未发生变化。尽管处于居家隔离状态，但基于运动和营养的LI改善了BCS的心脏代谢健康。
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