Cadet J L, Karoum F
Neuropsychiatry Branch, St. Elizabeth's Hospital, Washington, D.C. 20032.
Synapse. 1988;2(1):23-7. doi: 10.1002/syn.890020105.
Chronic treatment with iminodipropionitrile (IDPN) causes a behavioral syndrome characterized by lateral and vertical neck dyskinesias, hyperactivity, random circling, and increased startle response (the "ECC syndrome"). The effects of the neurotoxin on norepinephrine (NE), dopamine (DA), and their metabolites were evaluated in the hypothalamus and the striatum of IDPN-treated animals. Urinary excretion of the amines was also measured. There was no significant persistent change in central metabolism of dopamine. There was a transient increase in NE metabolism in the hypothalamus after the third injection of IDPN that lasted until the development of the syndrome at 7 days of drug treatment. Urinary excretion of NE and its metabolites was increased on the day that the syndrome developed. Urinary excretion of homovanillic acid was persistently decreased throughout and after cessation of drug treatment. There was no change in the excretion of either dopamine or dihydroxyphenyl acetic acid. The ratio of total NE/total DA excreted by IDPN-treated rats was the inverse of that of control animals. These results suggest that persistent dyskinesias may be associated with a relative increase in facilitatory NE-dependent mechanisms at the cortical, subcortical, or spinal cord level.
用亚氨基二丙腈（IDPN）进行长期治疗会导致一种行为综合征，其特征为颈部横向和纵向运动障碍、多动、随机转圈以及惊吓反应增强（“ECC综合征”）。在接受IDPN治疗的动物的下丘脑和纹状体中评估了这种神经毒素对去甲肾上腺素（NE）、多巴胺（DA）及其代谢产物的影响。还测量了胺类的尿排泄量。多巴胺的中枢代谢没有显著的持续变化。在第三次注射IDPN后，下丘脑的NE代谢出现短暂增加，一直持续到药物治疗7天时综合征出现。在综合征出现当天，NE及其代谢产物的尿排泄量增加。在整个药物治疗期间及停药后，高香草酸的尿排泄量持续下降。多巴胺或二羟基苯乙酸的排泄没有变化。接受IDPN治疗的大鼠排泄的总NE/总DA的比值与对照动物相反。这些结果表明，持续性运动障碍可能与皮质、皮质下或脊髓水平上促进性NE依赖机制的相对增加有关。
