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外阴痛-从神经生物学角度接受新认识的时候到了。

Vulvodynia-It Is Time to Accept a New Understanding from a Neurobiological Perspective.

机构信息

Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain.

Gynecology Section, Clinical Area of Women's Diseases, La Fe University Hospital, 46010 Valencia, Spain.

出版信息

Int J Environ Res Public Health. 2021 Jun 21;18(12):6639. doi: 10.3390/ijerph18126639.

DOI:10.3390/ijerph18126639
PMID:34205495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8296499/
Abstract

Vulvodynia is one the most common causes of pain during sexual intercourse in premenopausal women. The burden of vulvodynia in a woman's life can be devastating due to its consequences in the couple's sexuality and intimacy, in activities of daily living, and psychological well-being. In recent decades, there has been considerable progress in the understanding of vulvar pain. The most significant change has been the differentiation of vulvar pain secondary to pathology or disease from vulvodynia. However, although it is currently proposed that vulvodynia should be considered as a primary chronic pain condition and, therefore, without an obvious identifiable cause, it is still believed that different inflammatory, genetic, hormonal, muscular factors, etc. may be involved in its development. Advances in pain neuroscience and the central sensitization paradigm have led to a new approach to vulvodynia from a neurobiological perspective. It is proposed that vulvodynia should be understood as complex pain without relevant nociception. Different clinical identifiers of vulvodynia are presented from a neurobiological and psychosocial perspective. In this case, strategies to modulate altered central pain processing is necessary, changing the patient's erroneous cognitions about their pain, and also reducing fear avoidance-behaviors and the disability of the patient.

摘要

外阴痛是绝经前妇女性交过程中疼痛的最常见原因之一。由于外阴痛对夫妻性生活和亲密关系、日常生活活动以及心理健康的影响,其对女性生活的影响可能是毁灭性的。近几十年来,人们对外阴疼痛的认识有了相当大的进展。最重要的变化是将继发于病理或疾病的外阴疼痛与外阴痛区分开来。然而,尽管目前提出外阴痛应被视为一种原发性慢性疼痛疾病,因此没有明显可识别的病因,但仍认为不同的炎症、遗传、激素、肌肉等因素可能参与其发展。疼痛神经科学和中枢敏化范式的进步使人们从神经生物学的角度对外阴痛有了新的认识。有人提出,外阴痛应被理解为无相关伤害感受的复杂疼痛。从神经生物学和心理社会的角度提出了不同的外阴痛临床标识。在这种情况下,有必要调节中枢疼痛处理的改变,改变患者对疼痛的错误认知,减少恐惧回避行为和患者的残疾。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2add/8296499/d316e146f463/ijerph-18-06639-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2add/8296499/d316e146f463/ijerph-18-06639-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2add/8296499/d316e146f463/ijerph-18-06639-g001.jpg

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本文引用的文献

1
New Insights about Chronic Pelvic Pain Syndrome (CPPS).慢性盆腔疼痛综合征(CPPS)的新见解。
Int J Environ Res Public Health. 2020 Apr 26;17(9):3005. doi: 10.3390/ijerph17093005.
2
Vulvodynia.外阴痛。
Nat Rev Dis Primers. 2020 Apr 30;6(1):36. doi: 10.1038/s41572-020-0164-2.
3
Pain Trajectories and Predictors: A 7-Year Longitudinal Study of Women With Vulvodynia.疼痛轨迹和预测因素:一项为期 7 年的外阴痛女性纵向研究。
患有外阴痛的意大利女性的心理、人际关系及生育相关特征:一项与对照组的比较研究
Int J Environ Res Public Health. 2025 Mar 30;22(4):527. doi: 10.3390/ijerph22040527.
4
Towards a better definition of nociplastic pain conditions: a psychological grounded study on fibromyalgia, chronic headache and vulvodynia.迈向对伤害感受性疼痛病症的更好定义:一项关于纤维肌痛、慢性头痛和外阴痛的心理学基础研究。
Eur J Psychotraumatol. 2025 Dec;16(1):2461434. doi: 10.1080/20008066.2025.2461434. Epub 2025 Feb 13.
5
Vulvodynia - A contemporary understanding and practical approach in primary care settings.外阴痛——基层医疗环境中的当代理解与实用方法
Malays Fam Physician. 2024 Dec 27;19:72. doi: 10.51866/rv.620. eCollection 2024.
6
Chronic Primary Pelvic Pain Syndromes in Women: A Comprehensive Review.女性慢性原发性盆腔疼痛综合征:综述
Cureus. 2024 Dec 1;16(12):e74918. doi: 10.7759/cureus.74918. eCollection 2024 Dec.
7
Help-seeking experiences and intimate partner support in vulvodynia: A qualitative exploration.阴痛患者的求助经历和伴侣支持:一项定性研究
Womens Health (Lond). 2024 Jan-Dec;20:17455057241241866. doi: 10.1177/17455057241241866.
8
Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females.友善行为:用于研究性行为对雌性生理、行为和神经可塑性变化影响的渐进式交配方式。
Front Behav Neurosci. 2023 Sep 28;17:1184897. doi: 10.3389/fnbeh.2023.1184897. eCollection 2023.
9
Treatment of Vestibulodynia with Submucosal Injections of IncobotulinumtoxinA into Targeted Painful Points: An Open-Label Exploratory Study.靶向痛点注射亚单位肉毒毒素 A 治疗前庭大腺痛:一项开放性探索性研究。
Toxins (Basel). 2023 Jul 25;15(8):476. doi: 10.3390/toxins15080476.
10
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J Sex Med. 2019 Oct;16(10):1606-1614. doi: 10.1016/j.jsxm.2019.07.018. Epub 2019 Aug 23.
4
Study on the prevalence and factors associated to vulvodynia in Spain.西班牙女性外阴痛的患病率及相关因素研究。
Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:121-124. doi: 10.1016/j.ejogrb.2019.06.005. Epub 2019 Jun 21.
5
Provoked vulvar vestibulodynia: Epidemiology in Europe, physio-pathology, consensus for first-line treatment and evaluation of second-line treatments.诱发性外阴前庭炎:欧洲的流行病学、生理病理学、一线治疗共识及二线治疗评估
J Gynecol Obstet Hum Reprod. 2019 Oct;48(8):685-688. doi: 10.1016/j.jogoh.2019.04.011. Epub 2019 Apr 30.
6
Pain Neuroscience Education for Adults With Chronic Musculoskeletal Pain: A Mixed-Methods Systematic Review and Meta-Analysis.针对患有慢性肌肉骨骼疼痛的成年人的疼痛神经科学教育:一项混合方法的系统评价与荟萃分析。
J Pain. 2019 Oct;20(10):1140.e1-1140.e22. doi: 10.1016/j.jpain.2019.02.011. Epub 2019 Mar 1.
7
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J Low Genit Tract Dis. 2019 Apr;23(2):161-163. doi: 10.1097/LGT.0000000000000461.
8
The IASP classification of chronic pain for ICD-11: chronic primary pain.国际疼痛学会(IASP)对 ICD-11 的慢性疼痛分类:慢性原发性疼痛。
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9
Environmental Exposure History and Vulvodynia Risk: A Population-Based Study.环境暴露史与外阴痛风险:一项基于人群的研究。
J Womens Health (Larchmt). 2019 Jan;28(1):69-76. doi: 10.1089/jwh.2018.7188. Epub 2018 Oct 10.
10
Pelvic Floor Muscle Morphometry and Function in Women With Primary and Secondary Provoked Vestibulodynia.原发性和继发性诱发性外阴痛女性的盆底肌肉形态和功能。
J Sex Med. 2018 Aug;15(8):1149-1157. doi: 10.1016/j.jsxm.2018.06.001. Epub 2018 Jul 20.